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Thursday, January 10

Proteomes in Profile

Eugene Kolker, The University of Washington School of Medicine, Seattle
Joint JIBS-JICS Seminar
9:30 AM — 10:30 AM, Dabney Hall, Room 575,
The University of Tennessee, Knoxville
Contact: Gary Sayler (, 865.974.8080


Large volumes of high-throughput mass spectrometry proteomics studies are being routinely conducted nowadays. They are ultimately aimed at better understanding biological processes by studying proteomes' profiles. The size and complexity of proteomics data hinders efforts to easily share, integrate, query and compare such profiles. We will overview our recent developments addressing these challenges, including the creation of MOPED (Model Organism Protein Expression Database, MOPED focuses on answering four fundamental questions:
1. What proteins are identified and where (organisms, tissues, localizations, pathways)?
2. How much of each protein is identified (relative and absolute expression)?
3. How does the knowledge of your current experiment compare to existing information?
4. How does this knowledge guide your next (experimental or computational) study?

We will illustrate MOPED usage in our collaborative research of beta cell biology. Finally, we will introduce you to a new community: DELSA Global (Data-Enabled Life Sciences Alliance,

About the Author
This Introductory seminar is meant to encourage an open dialogue and information exchange. Dr. Kolker is Head of Bioinformatics and High-throughput Analysis Laboratory, Seattle Children's Research Institute and affiliate Professor in the Departments of Biomedical Informatics and Medical Education and Pediatrics at the University of Washington. He is actively engaged in proteomic and metabolomics investigation in cardiac disease supported by NIH and McMillian foundation; Data intensive Investigation and Proteomics by NSF and Gordon and Betty Moore Foundation; and NSF for the 3DVirtual Cell. Dr. Kolker has been engage in a number of for profit and not-for-profit start-ups including DELSA Global and has Co-founded several informatics journals. He is Editor-in-Chief of OMICS Journal of Integrative Biology and is Associate Editor of Journal of Standards in Genomic Sciences. He has developed proteomic informatics tool Protein_Prophet, SPIRE and MOPE. Dr. Kolker serves on review panels and committees for NIH, NSF, DOE and Genome Canada and is Advisory Board member for Beta Cell Biology Consortium and Nuclear Receptor Signaling Atlas.