Calendar Details

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Thursday, January 31

Overview of the NSF Engineering Research Center for
Revolutionizing Metallic Biomaterials
and
ERC Investigations of Mg Corrosion and Corrosion-Resistant
Coatings for Use ion Biodegradable Medical Devices

Peter R. Seoane and Yeoheung Yun, North Carolina A & T State University, Greensboro
Materials Science and Technology Division Seminar
10:30 AM — 11:30 AM, Building 4500-S, Room A-177
Contact: Guang Ling Song (songg@ornl.gov), 865.574.4451

Abstract

First talk:
In 2008, a consortium of Universities led by North Carolina A&T State University was awarded a National Science Foundation Engineering Research Center (ERC) as part of the first class of Generation 3 Centers. The Director of the ERC for Revolutionizing Metallic Biomaterials, Jag Sankar, Ph.D., was charged with establishing a pre-eminent research capability based on the use of biodegradable magnesium alloys in medical devices, training a next generation workforce, encouraging STEM education and translating technologies in a manner that positively impacts regional and national economic development. A short overview of the Center's major activities toward these ends and opportunities for collaboration will be discussed.

Second talk:
This presentation will provide an overview of the fundamental corrosion science of Magnesium (Mg) and its alloys and corrosion-resistant coatings, especially as they relate to biomedical applications being developed by the Engineering Research Center for Revolutionizing Metallic Biomaterials (ERC-RMB). Understanding the biological and material factors that govern the corrosion kinetics and mechanisms is of prime importance with the emphasis of different types of corrosions. Attempts to mimic the corrosion within biological environments with solutions such as simulated body fluid (SBF) will be discussed highlighting the influence of corrosion products such as magnesium hydroxide, calcium phosphate, and magnesium carbonate. Developments of appropriate in vitro test methodologies that capture all relevant corrosion pathways and perturbations to those mechanisms due to relevant biological factors will be discussed for successful in vivo application of biodegradable metals that will truly revolutionize metallic biomaterials.

About the speakers
Dr. Seoane earned a Ph.D. in Chemistry from Lehigh University in 1984, and completed post-doctoral studies in the Trost lab at the University of Wisconsin, Madison in 1986. He has over 30 years of experience in the biomedical space, ranging from bench science to program leadership. His experience in academia and industry spans a broad range of therapeutic categories; including oncology, neuroscience, inflammatory disease, cardiovascular disease and diagnostic imaging, and has resulted in the filing of several IND's and the successful registration of TeslascanR in the United States. After 12 years in large pharma, Pete co-founded Eagle Vision Pharmaceutical Corp. and served as its Vice President of Research and Development. During his time with Eagle Vision, Pete also played a pivotal role in Business Development and Regulatory Affairs, and served as an independent consultant to the Pharmaceutical Industry. He currently serves as the Industrial Liaison Officer for the Engineering Research Center for Revolutionizing Metallic Biomaterials, headquartered at North Carolina A&T State University. Throughout his career, Pete has focused on the interface between business and science, working to ensure alignment between clinical / commercial needs and the conduct of scientific and clinical development programs. Dr. Seoane is the author of 32 publications and abstracts, and holds 13 US and international patents.

Dr. Yun earned a Ph.D. in Mechanical Engineering from University of Cincinnati at 2003 and completed post-doc, research associate and research professor at University of Cincinnati. Also he was working at the College of Medicine at University of Cincinnati for years. Then recently he has relocated to North Carolina A & T State University as associate professor in Bioengineering Program. His expertise is micro-medical device for biology and medical research as well as electrochemistry in term of corrosion, biosensor, carbon nanotube materials, and electrophysiology. He is currently a technical leader in corrosion area from Engineering Research Center for Revolutionizing Metallic Biomaterials (REC-RMB). He is teaching corrosion, medical micro-devices, systems biology and physiology. He is a member of editoral board in Nanomedicine and biotherapeutic discovery. Dr. Yun is the author of 50 publications and one book.