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Gary J. Van Berkel
Gary J. Van Berkel

Distinguished Research Scientist and Group Leader


B.A., Chemistry, Lawrence University, 1982
Ph.D., Analytical Chemistry, Washington State University, 1987
Postdoctoral Associate, Oak Ridge National Laboratory, 1987 - 1989
Research Mentors: Drs. Gary L. Glish and Scott A. McLuckey
Staff Research Scientist, Oak Ridge National Laboratory, 1989 - 2001
Senior Research Staff, Oak Ridge National Laboratory, 2001 - 2007
Distinguished Research Scientist, Oak Ridge National Laboratory, 2008 - present
UTK Joint Faculty Associate Professor, Bredesen Center for Interdisciplinary Research and Education, 2011
- present

C&E cover  

Research Interests:

Analytical Chemistry focusing on Organic and Biological Mass Spectrometry Fundamentals, Instrumentation and Applications

Fundamental ion source chemistry and analytical studies

     Solution chemistry and electrochemistry aspects of electrospray
        ionization
     Desorption electrospray ionization  
     Liquid-microjunction surface sampling probes
     Derivatization in electrospray mass spectrometry

Atmospheric pressure surface sampling and ionization methods for
    high throughput analysis and chemical imaging
    (http://www.ornl.gov/sci/ms_imaging_center/) of analytes on
    surfaces (TLC plates, electrophoresis gels, affinity arrays, tissue
    sections, etc.)

Interfacing electrochemistry and mass spectrometry

     Electrochemically-modulated elemental and molecular recognition
     Study of the non-volatile products of electrode reactions
     Study of the initial soluble n-mer products of electropolymerization
     Mimicking enzymatic redox processes with electrochemistry

Metabolomic measurements related to bioenergy production

Natural product analysis

Awards and Honors:

2013 ORNL Directors Award "Scientist of the Year"
for Outstanding Individual Accomplishment in Science and Technology.

2013 ORNL Award: Inventor of the Year

2013 Beynon Prize for best publication in
Rapid Communications in Mass Spectrometry.

2010 R&D 100 Award: Surface Sampling Probe for Mass Spectrometry

2009 Federal Laboratory Consortium (FLC) Southeast Region Excellence in Technology Transfer Project of the Year: Surface Sampling Probe for Mass Spectrometry

2005 Biemann Medal Winner

2003 ORNL Award: Science Communicator

Professional Societies:

American Society for Mass Spectrometry, Member

American Chemical Society, Member

 

Bibliographies:

Concentric Dual Channel Flow Probe

Discrete Droplet Probes

Laser Ablation Sampling with Liquid Phase Collection

Non-Concentric Dual Channel Flow Probes

Sealing Surface Sampling Probes

Single Channel Flow Probes

Solvent Droplet Plume/Stream Impact

Patents:

Pat. No.  

 Title

1

8,742,338

Systems and methods for laser assisted sample transfer to solution for chemical analysis

2

8,637,813

System and method for laser assisted sample transfer to solution for chemical analysis

3

8,519,330

Systems and methods for laser assisted sample transfer to solution for chemical analysis

4

8,497,473

Electrospray ion source with reduced analyte electrochemistry

5

8,486,703

Surface sampling concentration and reaction probe

6

8,384,020

Spatially resolved thermal desorption/ionization coupled with mass spectrometry

7

8,117,929

Control of the positional relationship between a sample collection instrument and a surface to be analyzed during a sampling procedure using a laser sensor

8

8,084,735

Pulsed voltage electrospray ion source and method for preventing analyte electrolysis

9

8,003,937

Electrospray ion source with reduced analyte electrochemistry

10

7,995,216

Control of the positional relationship between a sample collection instrument and a surface to be analyzed during a sampling procedure with image analysis

11

7,295,026

Automated position control of a surface array relative to a liquid microjunction surface sampler

12

6,952,013

Electrochemistry with porous flow cell

13

6,803,566

Sampling probe for microarray read out using electrospray mass spectrometry

14

6,784,439

Thin-channel electrospray emitter

15

6,677,593

Planar flow-by electrode capacitive electrospray ion source


Selected Publications:

(153)    Kertesz, V, Weiskittel, T. M.; Van Berkel, G. J. An Enhanced Droplet-Based Liquid Microjunction Surface Sampling System Coupled with HPLC-ESI-MS/MS for Spatially Resolved Analysis. Anal. Bioanal. Chem., submitted.

(152)    Ovchinnikova, O. S.; Bhandari, D.; Lorenz, M.; Van Berkel, G. J. Transmission Geometry Laser Ablation into a Non-Contact Liquid Vortex Capture Probe for Mass Spectrometry Imaging. Rapid Commun Mass Spectrom. 2014, 28, 1665-1673.

(151)    Kertesz, V.; Van Berkel, G. J. Sampling Reliability, Spatial Resolution, Spatial Precision, and Extraction Efficiency in Droplet-Based Liquid Microjunction Surface Sampling. Rapid Commun Mass Spectrom. 2014, 28, 1553-1560.

(150)     Lorenz, M.; Ovchinnikova, O. S.; Van Berkel, G. J.  Fully Automated Laser Ablation Liquid Capture Surface Analysis using NanoElectrospray Ionization Mass Spectrometry.”  Rapid Commun Mass Spectrom., 2014, 28, 1312-1320.

(149)     Kertesz, V.; Paranthaman, N.; Moench, P.; Catoire, A.; Flarakos, J.; Van Berkel, G. J.  “Liquid Microjunction Surface Sampling-HPLC-MS/MS Profiling of Acetominophen, Terfenadine, and Their Metabolites in Whole-Body Rat Thin Tissue Sections.”  Bioanalysis, in press.

(148)     Lorenz, M.; Ovchinnikova, O. S.; Kertesz, V.; Van Berkel, G. J.  Controlled Resonant Surface Tapping-Mode Scanning Probe Electrospray Ionization Mass Spectrometry Imaging.”  Anal. Chem., 2014, 86, 3146-3152.

(147)     Ovchinnikova, O. S.; Kjoller, K.; Hurst, G. B.; Pelletier, D. A.; Van Berkel, G. J.  Atomic Force Microscope Controlled Topographical Imaging and Proximal Probe Thermal Desorption/Ionization Mass Spectrometry Imaging.  Anal. Chem. 2014, 86, 1083-1090.

(146)     Ovchinnikova, O. S.; Lorenz, M.; Kertesz V.; Van Berkel, G. J.  Laser Ablation Sampling of Materials Directly into the Formed Liquid Microjunction of a Continuous Flow Surface Sampling Probe/Electrospray Ionization Emitter for Mass Spectral Analysis and Imaging.”  Anal. Chem. 2013, 85, 10211-10217.

(145)    Van Berkel, G. J.; Kertesz, V.  “Continuous Flow Liquid Microjunction Surface Sampling Probe Connected On-lIne with HPLC/MS for Spatially Resolved Analysis of Small Molecules and Proteins.”  Rapid Commun. Mass Spectrom. 2013, 27, 1329-1334.

(144)    Lorenz, M.; Ovchinnikova, O. S.; Kertesz V.; Van Berkel, G. J.  Laser Microdissection and Atmospheric Pressure Chemical ionization Mass Spectrometry Coupled for Multimodal Imaging. Rapid Commun. Mass Spectrom. 2013, 27, 1429-1436.

(143)    Kertesz V.; Van Berkel, G. J.  “Automated Liquid Microjunction Surface Sampling-HPLC-MS/MS Analysis of Drugs and Metabolites in Whole-Body Thin Tissue Sections,” Bioanalysis 2013, 5, 819-826.

(142)    Bhandari, D.; Kertesz, V.; Van Berkel, G. J.  “Rapid Quantitation of Ascorbic and Folic Acids in SRM 3280 Multivitamin/Multielement Tablets using Flow-Injection Tandem Mass Spectrometry,” Rapid Commun. Mass Spectrom. 2013, 27, 163-168.

(141)    Bhandari, D.; Van Berkel, G. J.  “Evaluation of Flow-Injection Tandem Mass Spectrometry for Rapid and High-Throughput Quantitative Determination of B-Vitamins in Nutritional Supplements,” J. Agric. Food Chem. 2012, 60, 8356-8362.

(140)    Parson, W. B.; Koeniger, S. L.; Johnson, R. W.; Erickson, J.; Tian, Y.; Stedman, C.; Schwartz, A.; Tarcsa, E.; Cole, R.; Van Berkel, G.J.  “Analysis of Chloroquine and Metabolites Directly from Whole-body Animal Tissue Sections by Liquid Extraction Surface Analysis (LESA) and Tandem Mass Spectrometry,” J. Mass Spectrom. 2012, 47, 1420-1428.

(139)  Custelcean, R.; Bonnesen, P. V.; Duncan, N. C.; Zhang, X.; Watson, L. A.; Van Berkel, G.; Parson, W. B.; Hay, B. P. “Urea-Functionalized M4L6 Cage Receptors: Anion-Templated Self-Assembly and Selective Guest Exchange in Aqueous Solutions,” J. Am. Chem. Soc. 2012, 134, 8525-8534.

(138)  Van Berkel, G. J.; Kertesz, V. “ Utilizing the Inherent Electrolysis in a Chip-Based Nanoelectrospray Emitter System to Facilitate Selective Ionization and Mass Spectrometric Analysis of Alkylporphyrins,” Anal. Bioanal. Chem. 2012, 403, 335-343.

(137)  Walworth, M. J.; Stankovich, J. J.; Van Berkel, G. J.; Schulz, M.; Minarik, S.  “High Performance Thin-Layer Chromatography Plate Blotting for Liquid Microjunction Surface Sampling Probe Mass Spectrometric Analysis of Analytes Separated on a Wettable Plate,”  Rapid. Commun. Mass Spectrom. 2012, 26, 37-42.

(136)  Ovchinnikova, O. S.; Kertesz, V.; Van Berkel, G. J.  “Combining Transmission Geometry Laser Ablation and a Non Contact Continuous Flow Surface Sampling Probe/Electrospray Emitter for Mass Spectrometry-Based Chemical Imaging,”  Rapid. Commun. Mass Spectrom. 2011, 25, 3735-3740.

(135)  Parson, W. B.; Schneider, B. B.; Kertesz, V.; Corr, J. J.; Covey, T. R.; Van Berkel, G. J.  “Rapid Analysis of Isobaric Exogenous Metabolites by Differential Mobility Spectrometry – Mass Spectrometry,”  Rapid. Commun. Mass Spectrom. 2011, 25, 3382-3386.

(134)  ElNaggar, M. S.; Van Berkel, G. J.  “Liquid Microjunction Surface Sampling Probe Fluid Dynamics:  Characterization and Application of an Analyte Plug Formation Operational Mode,”  J. Am. Soc. Mass Spectrom. 2011, 22, 1737-1743.

(133)    Walworth, M. J.; ElNaggar, M. S.; Stankovich, J. J.; Witkowski, C.; Norris, J. L.; Van Berkel G. J.  “Direct Sampling and Analysis from Solid Phase Extraction Cards using an Automated Liquid Extraction Surface Analysis Nanoelectrospray Mass Spectrometry System,”  Rapid Commun. Mass Spectrom. 2011, 25, 2389-2396.

(132)    Blatherwick, E.Q.; Van Berkel, G.J.; Pickup, K.; Beaudoin, M-E., Cole, R.; Day, J. M.; Johannson, M. K.; Iverson, S.; Scrivens, J. H.; Weston, D. J.  “Utility of Spatially Resolved Atmospheric Pressure Surface Sampling Ionization Technqiues as Alternatives to Mass Spectrometric Imaging (MSI) Techniques in Drug Metabolism,” Xenobiotica 2011, 41, 720-734.

(131)     Ovchinnikova, O. S.; Nikiforov, M. V.; Bradshaw,J. A.; Jesse, S.; Van Berkel, G. J.  “Combined Atomic Force Microscope-Based Topographical Imaging and Nanometer Scale Resolved Proximal Probe Thermal Desorption/Electrospray Ionization-Mass Spectrometry,”  ACSNano 2011, 5, 5526-5531.

(130)   ElNaggar, M. S.; Barbier, C.; Van Berkel, G. J.  “Liquid Microjunction Surface Sampling Probe Fluid Dynamics:  Computational and Experimental Analysis of Coaxial Intercapillary Positioning Effects on Sample Manipulation,”  J. Am. Soc. Mass Spectrom. 2011, 22, 1157-1166.

(129)   Ovchinnikova, O. S.; Kertesz, V.; Van Berkel, G. J.  “Combining Laser Ablation/Liquid Phase Collection Surface Sampling and High-Performance Liquid Chromatography Electrospray Ionization Mass Spectrometry,”  Anal. Chem. 2011, 83, 1874-1878.

(128)  Ovchinnikova, O. S.; Kertesz, V.; Van Berkel, G. J.  “Molecular Surface Sampling and Chemical Imaging Using Proximal Probe Thermal Desorption/Secondary Ionization Mass Spectrometry,”  Anal. Chem. 2011, 83, 598-603.


 Provided by Oak Ridge National Laboratory's Chemical Sciences Division 
Rev: September 2014