Sponsored by the U.S. Department of Energy Human Genome Program
Human Genome News Archive Edition
Human Genome News, July 1994; 6(2)
Investigators at the U.K. Imperial Cancer Research Fund (ICRF) have compiled much of the available human major histocompatibility complex (MHC) genetic and physical data into a publicly available database. MHCDB uses software developed for the Caenorhabditis elegans project to access, retrieve, and display MHC data. Information in release 1-0 includes
MHCDB also has a tool for examining the antigen's structure from within the database and the ability to examine the variability of class I allele sequences within the three-dimensional structure of the class I antigen. Other features will appear in future extensions to the core of ACEDB, the C. elegans database. These will include interfaces to sequence- analysis software such as GRAIL, which detects coding regions in human sequences, and to the Pythia programs, which find repetitive elements and classify Alu repeats into Alu subfamilies. Information on Alu repeats can provide insights into MHC evolution.
MHCDB is funded by the European Economic Community's BioMed1 program.
The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v6n2).
The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.
Published from 1989 until 2002, this newsletter facilitated HGP communication, helped prevent duplication of research effort, and informed persons interested in genome research.