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Sponsored by the U.S. Department of Energy Human Genome Program

Human Genome News Archive Edition

Human Genome News, Nov. 1994; 6(4):10

University of Utah

UNIVERSITY OF UTAH (UU)
(NIH, established 1990)
RAYMOND F. GESTELAND and ROBERT B. WEISS, Directors
CONTACT: Gesteland (801/581-5190, Fax: /585-3910, rayg@gene1.med.utah.edu); UU; 6160 Eccles Genetics Bldg.; Salt Lake City, UT 84112.
OTHER KEY RESEARCHERS
Jeff Botkin
Peter Cartwright
Mark Leppert
Harold Swerdlow

MAJOR GOALS

  • Development of resources and technologies for sequencing and mapping, including (1) organized front-end strategies for large sequencing projects; (2) DNA sequencing technology, including capillary and multiplex approaches; (3) informatics tools for automation of large-scale sequencing and for distributive database searches; (4) pilot large-scale sequencing; and (5) automated genotyping technology.

MAJOR ACCOMPLISHMENTS

  • Development of a sensitive fluorogenic assay suitable for DNA detection on membranes; an automated chamber for unattended, sequential probing of multiplexed DNA sequencing patterns, including on-board image acquisition and base calling; magnetic bead technology for DNA preparation; transposon system for ordered sequencing of large fragments in the multiplex system; efficient multiplex method for large-scale genotyping; pilot-scale sequencing of human and mouse genomic regions; informatics tools for automating sequencing systems, transposon mapping, and database management searching; 12 mapping projects in the visitors' laboratory; and ethical, legal, and social issues seminars and projects.

AVAILABLE RESOURCES


HGMIS staff

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The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v6n4).

Human Genome Project 1990–2003

The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.

Human Genome News

Published from 1989 until 2002, this newsletter facilitated HGP communication, helped prevent duplication of research effort, and informed persons interested in genome research.