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Human Genome News Archive Edition

Human Genome News, Nov. 1994; 6(4):10

University of Texas Health Science Center at San Antonio

UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO (UTHSCSA)
(NIH, established 1992)
SUSAN L. NAYLOR, Director
CONTACT: Naylor (210/567-3842, Fax: -6781, naylor@uthscsa.edu); UTHSCSA; 7703 Floyd Curl Drive; San Antonio, TX 78284-7762.
OTHER KEY RESEARCHERS
Peter Cartwright (Univ. of Utah)
David Housman (Massachusetts Institute of Technology)
Robin Leach
Peter O'Connell
Stephanie Sherman (Emory Univ.)
Brad Windle

MAJOR GOALS

  • Construction of radiation hybrid, genetic linkage, and contig maps for human chromosome 3.
  • Development of 2500 sequence tagged sites at 100-kb intervals on chromosome 3.
  • Development of a chromosome 3-specific database (with the Univ. of Utah genome center).

MAJOR ACCOMPLISHMENTS

  • Production of framework hybrids that divide chromosome 3 into 23 regions.
  • Construction of genetic linkage maps (one with 120 SSRs and 52 markers and another with 198 dinucleotide repeats) and a radiation hybrid map with 150 loci.
  • Yeast artificial chromosome contigs covering over 80% of chromosome 3. Database contains 20,000 yeast artificial chromosome X sequence tagged site and YACx probe records.
  • Characterization of 450 simple repeat polymorphisms for chromosome 3.
  • Design and assembly of polymerase chain reaction primers for 81 genes and RFLPs.
  • Development of a semiautomated system for polymerase chain reaction reactions and automated gel loading robotics for both Centre d'Etude du Polymorphisme Humain screening and radiation hybrids.

AVAILABLE RESOURCES

  • Framework hybrids for chromosome 3. Polymerase chain reaction primers for polymorphic dinucleotide repeats and genes mapping to chromosome 3.
  • Scheme for automating Centre d'Etude du Polymorphisme Humain typing.
  • Chromosome 3-specific database.
  • Pre- and postdoctoral training in human genome research.
  • Yeast artificial chromosome clones, chromosome 3 cosmid library, P1 screening.

HGMIS staff

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Human Genome Program, U.S. Department of Energy, Human Genome News (v6n4).

Human Genome Project 1990–2003

The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.

Human Genome News

Published from 1989 until 2002, this newsletter facilitated HGP communication, helped prevent duplication of research effort, and informed persons interested in genome research.