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Human Genome News Archive Edition

Human Genome News, Nov. 1994; 6(4):12

Washington University School of Medicine

WASHINGTON UNIVERSITY SCHOOL OF MEDICINE (WUSM)
GENOME SEQUENCING CENTER
(NIH, established 1993)
ROBERT H. WATERSTON, Director
CONTACT: Paula Kassos, Administrator (314/286-1802, Fax: -1810, pkassos@watson.wustl.edu); WUSM, Box 8501; 4444 Forest Park Blvd.; St. Louis, MO 63108.
OTHER KEY RESEARCHERS
Warren R. Gish
LaDeana Hillier
H. Mark Johnston
Elaine R. Mardis
David J. States
Mark Vaudin
Richard K. Wilson
C. elegans Sequencing Collaborators:
Sanger Centre (Medical Research Council, U.K.), John Sulston, Director.
Contact: Jane Rogers, Administrator (+44-223/834938, Fax: /494919, jrh@sanger.ac.uk); Sanger Centre; Hinxton Park; Hinxton, Cambridge; UK CB10 1RQ.
Other Key Researchers (Sanger Centre):
Mary Berks
Alan Coulson
Simon Dear
Richard Durbin
Karen Thomas
Other Collaborators:
Philip Green (Univ. of Wash., Seattle)
Roger Staden [MRC Laboratory of Molecular Biology (Cambridge, U.K.)]
Jean Thierry-Mieg [Centre National de la Recherche Scientifique (Montpellier, France)]

MAJOR GOALS

  • Complete determination by 1998 of genomic sequence (100 Mb) of the nematode C. elegans (with the Sanger Centre).
  • Contribution to the rapid completion of the yeast S. cerevisiae genome Sequence with production of 2 to 3 Mb in 2 years.
  • Development of technology and software for efficient large-scale genome sequencing.

MAJOR ACCOMPLISHMENTS

  • Completion of 8 Mb of nematode genomic sequence, containing about 1500 predicted genes (with the Sanger Centre).
  • Completion of 1 Mb of yeast genomic sequence, including the complete sequence of chromosome VIII.
  • Adaptation of methods to human genomic sequencing and application to human 16p21 cosmids.
  • Development and implementation of the object-oriented database ACEDB to provide the sequence and physical map in the context of other information available for the nematode (with Durbin and Thierry-Mieg).
  • Improvements in the Staden assembly-editing package (xbap and xgap); scripts to automate data transfer, handling, and analysis with improved data tracking; improved base calling and development of alternative assembly methods (with Green and Thierry-Mieg).
  • Development of GENEFINDER, a program that accurately and rapidly predicts genes in nematode genomic DNA.

AVAILABLE RESOURCES

  • Nearly complete C. elegans clonal physical map with cosmid and yeast artificial chromosome clones.
  • Nearly complete S. cerevisiae clonal physical map, with cosmid and lambda clones.
  • 1500 sequence-tagged and mapped cDNA clones.
  • Software packages, including ACEDB, GENEFINDER, xbap/xgap, oligoselection, data tracking, and processing suites.

HGMIS staff

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Human Genome Program, U.S. Department of Energy, Human Genome News (v6n4).

Human Genome Project 1990–2003

The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.

Human Genome News

Published from 1989 until 2002, this newsletter facilitated HGP communication, helped prevent duplication of research effort, and informed persons interested in genome research.