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Human Genome News Archive Edition
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Human Genome News, Nov. 1994; 6(4):12

Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology

WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH and MASSACHUSETTS INSTITUTE OF TECHNOLOGY

  • (NIH, established 1990)
  • ERIC S. LANDER, Director
  • David Page and Nat Goodman, Associate Directors
  • CONTACT: Lander (617/258-5192, Fax: -6505; lander@mitwibr.bitnet); Whitehead Institute for Biomedical Research; Nine Cambridge Center; Cambridge, MA 02142.

OTHER KEY RESEARCHERS

  • Daniel Cohen (Centre d'Etude du Polymorphisme Humain)
  • Joe Nadeau (Jackson Laboratory)
  • Shirley Tilghman (Princeton Univ., Howard Hughes Medical Institute)

MAJOR GOALS

  • Construction in 3 years of a low-resolution physical map of the human genome based on 8500 sequence tagged sites.
  • Construction of genetic and physical maps of the mouse genome, including a high-resolution genetic map consisting of 6000 SSLPs, integrating 25% of these markers with the Copeland-Jenkins cross showing gene location.
  • Production within 5 years of a low-resolution physical contig map (average size, 10 to 20 Mb) of the mouse genome based on 10,000 sequence tagged sites.

MAJOR ACCOMPLISHMENTS

  • Construction of a mouse genetic map having 5250 SSLPs and human sequence tagged site-content data with >=3700 sequence tagged sites.
  • Construction of a mouse genome yeast artificial chromosome library with 700-kb average inserts.
  • Implementation of an efficient approach for screening entire yeast artificial chromosome libraries.
  • Implementation of a center-pioneered object-oriented database for genomic data.
  • Introduction of yeast artificial chromosomes into mouse embryonic stem cell lines and mouse germline.
  • Development of new technologies to increase automation ("waffle iron" thermocycler, which can handle 16 microtitre dishes at once), sequence tagged site screening robot.

AVAILABLE RESOURCES

Mouse genome yeast artificial chromosome library (Research Genetics, 800/533-4363;Genome Systems, 800/248-7609). Primers for mouse SSLPs (Research Genetics). Software for choosing primers and genetic mapping. "Waffle iron" thermocycler prototype (Intelligent Automation Systems, Cambridge, MA). Data are available by (1) anonymous ftp (genome.wi.mit.edu; login, anonymous; password, user e-mail address); (2) internet e-mail using a database e-mail server (for copies of query forms, send message to genome_database@genome.mit.edu with help in either subject line or body text); and (3) WWW at http://www-genome.wi.mit.edu Newsletter available via WWW URL and e-mail (newsletter@genome.mit.edu).

HGMIS staff

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The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v6n4).

Human Genome Project 1990–2003

The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.

Human Genome News

Published from 1989 until 2002, this newsletter facilitated HGP communication, helped prevent duplication of research effort, and informed persons interested in genome research.