Sponsored by the U.S. Department of Energy Human Genome Program
Human Genome News Archive Edition
Human Genome News, September 1991; 3(3)
A 2-day conference incorporating three meetings on the genetic and physical maps of human chromosome 4 was held June 22-23 in Philadelphia. Some 25 participants from 5 countries attended the conference, which was sponsored by the Centre d'Etude du Polymorphisme Humain (CEPH), NIH, and the Fox Chase Cancer Center.
The CEPH consortium group developing the genetic linkage map of chromosome 4 discussed marker inclusion, map development, significance criteria, and checks for genotyping errors. From CEPH data, Ken Buetow (Fox Chase Cancer Center) generated a preliminary 33-point multilocus map that encompassed all of chromosome 4 at an average resolution of about 8 cM.
The facioscapulohumeral muscular dystrophy consortium discussed recent data pooling for linkage analysis of this disorder, which has been mapped to 4q35-4qter.
In the plenary meeting, Peter Pearson (Johns Hopkins University) gave an overview of consensus vs component maps; he made the Genome Data Base (GDB) available to investigators during the conference. A number of individual presentations described chromosome 4 genetic and physical maps and specific loci or genes:
Discussions included human chromosome 4 mapping resources now being developed and made available both by individual investigators and through the human genome center headed by Myers at USCF. These resources will help to generate high-resolution maps of regions near identified chromosome 4 genes and to develop chromosome 4 maps (radiation, genetic, and clone-based) not based solely on genes and genetic disorders.
Participants discussed organization of future workshops around GDB. The second chromosome 4 conference will be held June 13-14, 1992, in Leiden, Netherlands.
For complete proceedings of the conference, contact
For information on the next chromosome 4 workshop, contact
Reported by Jeffrey C. Murray, University of Iowa
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Human Genome Program, U.S. Department of Energy, Human Genome News (v3n3).
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