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Human Genome News, July 1992; 4(2)

Genome Report Card Summarizes Progress

The Genome Report Card, a summary prepared by the National Center for Human Genome Research (NCHGR), presents an overview of progress made toward the 5-year chromosome mapping and DNA sequencing goals of the U.S. Human Genome Project. The report card is based on data from the GDB Human Genome Data Base, GenBank®, and primary publications. Additionally, genetic linkage map information is derived from the Human Genome Mapping Workshop 10 (HGM 10), the Centre d'Etude du Polymorphisme Humain (CEPH), and the NCHGR Index Map project.

The following information is reported for each human chromosome:

  • Sequence. The total number of kilobase pairs of DNA sequenced is shown in "bins" that represent sequence localized to (1) a single cytogenetic band, (2) a chromosomal region larger than a band but smaller than or equal to a chromosome arm, or (3) the chromosome, but not to a specific arm or band. The total amount of sequence localized to the chromosome and the approximate degree of completion are indicated. The percentage-completed figure is based on an estimate of the total amount of DNA in each chromosome. These data are taken from GDB and GenBank.
  • Contigs (if available). Published overlapping clone contigs of 1 Mb or more or ordered sets of contigs essentially covering a chromosomal region of 1 Mb or more are diagramed. The total length of contigs localized to the chromosome is shown, and an estimate of the percentage of the chromosome covered by contigs is provided. The percentage-completed figure is based on an estimate of the total amount of DNA in each chromosome. Data are from primary publications.
  • Genes. Total number of mapped genes is shown. The percentage-completed number is based on an estimate of 100,000 genes in the human genome and assumes that genes are distributed proportionate to chromosome length. Data are from GDB.
  • Linkage maps (if available). Sex-averaged linkage maps are shown. CEPH consortium maps are as published; index maps are as reported to NCHGR by the investigators; HGM 10 maps are those published by the Human Genome Mapping Workshop 10 Linkage Committee; and EUROGEM maps are those published by the EUROGEM consortium. High-resolution and framework maps will be added as they become available.
  • STSs. All unique anonymous DNA segment markers that can be assayed with polymerase chain reaction primers are included. Data are from GDB.

The March 1992 edition of the Genome Report Card constitutes the information baseline with which future data can be compared to assess progress. (Copies of the booklet are available from Office of Communications; NIH NCHGR; Building 38A, Room 617; Bethesda, MD 20892; 301/402-0911; Fax: 301/480-2770.)

HGMIS Staff

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The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v4n2).

Human Genome Project 1990–2003

The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.

Human Genome News

Published from 1989 until 2002, this newsletter facilitated HGP communication, helped prevent duplication of research effort, and informed persons interested in genome research.