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Human Genome News, November 1992; 4(4)
Extensive sections on the Human Genome Project are included in recent publications from three DOE national laboratories:
Lawrence Berkeley Laboratory (LBL). "Unraveling the Genetic Message" describes genome program goals and projects under way at LBL, with special emphasis on informatics and the automation of laboratory procedures, instrumentation, and technology. LBL Research Review 17(1), 2-15 (Spring 1992). [Available from LBL Research Review; LBL; Building 50C; Berkeley, CA 94720 (510/486-5771).]
Lawrence Livermore National Laboratory (LLNL). "The Human Genome Project" discusses basic molecular genetics; advances in informatics and instrumentation; and the application of mapping and sequencing procedures to the genome program, particularly progress in chromosome 19 mapping strategies, techniques, and data analysis at LLNL. Information on the National Laboratory Gene Library Project is also included. Energy and Technology Review, 29-62 (April-May 1992). [Available from Leilani Corell; LLNL; Bldg. 361, MS 452; P.O. Box 808; Livermore, CA 94551-9900 (510/423-3841)] or from National Technical Information Service (NTIS); U.S. Department of Commerce; 5285 Port Royal Road; Springfield, VA 22161.]
Oak Ridge National Laboratory (ORNL). "New Technologies for DNA Sequencing" and "Covering All the Bases: ORNL Probes the Human Genome" describe sequencing research and technologies being developed at ORNL. These activities include stable isotope sequencing, luminescent labeling systems, high-speed gel-less sequencing methods based on mass spectroscopy and hybridization, DNA imaging by atomic force and scanning tunneling microscopy, supercomputer analysis of DNA-carcinogen interactions, and Gene Recognition and Analysis Internet Link (GRAIL) software. ORNL investigators are using insertional and targeted mutagenesis and homologous recombination to study mouse-human homologies; develop physical, functional, and mutation maps of the mouse genome; and predict functions of the corresponding regions of the human genome. Oak Ridge National Laboratory Review 25(1), 18-39 (1992). [Available from ORNL Review; Bldg. 4500S, MS 6144; P.O. Box 2008; Oak Ridge, TN 37831-6144 (615/574-7183 or -6974) or from NTIS at the address above.]
HGMIS Staff
The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v4n4).
The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.
Published from 1989 until 2002, this newsletter facilitated HGP communication, helped prevent duplication of research effort, and informed persons interested in genome research.
