Human Genome Project Information. Click to return to home page.

Sponsored by the U.S. Department of Energy Human Genome Program

Human Genome News Archive Edition

Human Genome News, March 1993; 4(6)

GENOME CENTER:

Baylor College of Medicine

(NIH; established 1990)

DIRECTORS:
C. Thomas Caskey
Andrea Ballabio and David L. Nelson, Associate Directors

CONTACTS:
Sandra McMurtry, Administrator
(713/798-6524, Fax: -5386)

David Nelson
(-3122; nelson@bcm.tmc.edu)

Baylor College of Medicine
Institute for Molecular Genetics
One Baylor Plaza
Houston, TX 77030-3498.

OTHER KEY RESEARCHERS:
Antonio Baldini, Charles Lawrence, A. Craig Chinault, Edward McCabe, Richard A. Gibbs

MAJOR GOALS:
Six core facilities provide support for independently funded physical mapping and positional cloning projects and development of technology, with emphasis on chromosomes 6, 15, 17, and X.

MAJOR ACCOMPLISHMENTS:

  • Identification of several new disease loci, including Fragile X syndrome, DM, CMT disease, Kallman syndrome, and Lowe syndrome.
  • Identification of >1000 YAC clones by PCR screening for target chromosomes.
  • Assembly of contigs in target regions (many contigs >1 Mb from X, 17, 6, and 15).
  • Development of methods for YAC characterization and contig assembly.
  • Development of GDB Lite, a database incorporating GDB chromosome data in a user-friendly format. Also development of a library screening and clone characterization database capable of periodic automatic submission to GDB.
  • Completion of moderate-scale sequencing projects encompassing over 200 kb of human DNA from the X and other chromosomes (including the genes for DMD, XIST, FRAXA, and DM).
  • Establishment of several hundred cell lines from patients with chromosome-linked disorders.
  • Production of detailed physical map of Xpter-Xp21.

AVAILABLE RESOURCES:

  • Total human YAC libraries (CEPH and Washington Univ.).
  • Chromosome X YAC libraries (Baylor and CHOP).
  • Chromosome 17 and X cosmid libraries (LANL, LLNL).
  • Screening service for chromosome 17p.
  • Numerous patient cell lines and chromosome mapping cell panels for 6, 17, and X (hybrids, deletions, etc.).
  • STSs and YACs for many loci on target chromosomes.
  • Database software.
  • NCHGR predoctoral training grant (Chinault).

    Genome Center Acronym List


    HGMIS Staff

    Return to List of Genome Centers

    Return to Table of Contents