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Human Genome News Archive Edition

Human Genome News, July 1993; 5(2)

Human Chromosome Workshop

Chromosome 8

The First International Human Chromosome 8 Workshop was held May 2-4 at the University of British Columbia, Vancouver, Canada. The conference, which was attended by 23 participants from Australia, Europe, and North America, was supported by CGAT/CTAG (Canadian Genome Analysis & Technology Program, Programme Canadien de Technologie & d'Analyse du Genome) as well as by NIH, DOE, and agencies in other participating countries.

Genetic Maps. Stephen Daiger (University of Texas, Houston) reported that 17 laboratories had submitted data on 142 systems representing 117 different loci. The Centre d'Etude du Polymorphisme Humain consortium map, which will include data submitted by the workshop deadline, is in the error-checking stage and is expected to be submitted for publication by early fall.

Physical Maps. Physical mapping of LGCR (Langer-Giedion chromosome region) continues. Hermann-Josef Luedecke (Institut fuer Humangenetik, Universitaetsklinikum, Essen, Germany) reported sequence tagged sites from an 8q24.1 microdissection library. Dan Wells (University of Houston) announced the construction of yeast artificial chromosome contigs for the same region.

Disease Loci. Three new disease loci assignments were reported. Kamel Ben Othmane (Duke University) described a recessive form of CMT (Charcot-Marie-Tooth disease) in Tunisians that maps to 8q. Robin Leach (University of Texas, San Antonio) reported a family with benign neonatal epilepsy (EBN2) mapping to 8q. Multiple exostoses (MEX) in some families maps to LGCR. Genetic heterogeneity in MEX was noted by Susan Blanton (University of Virginia, Charlottesville), with the majority of families segregating the EXT1 locus on 8q24.

Resources. Construction of new radiation hybrid cell panels was announced by a number of laboratories, while extension of an existing cell hybrid panel was reported by Michael Wagner (University of Houston).

A second workshop, to be held in Oxford, England, in September 1994, will be organized by Nigel Spurr (Imperial Cancer Research Fund).


[Stephen Wood, University of British Columbia, Internet: swood@unixg.ubc.ca]

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Human Genome Program, U.S. Department of Energy, Human Genome News (v5n2).

Human Genome Project 1990–2003

The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.

Human Genome News

Published from 1989 until 2002, this newsletter facilitated HGP communication, helped prevent duplication of research effort, and informed persons interested in genome research.