Sponsored by the U.S. Department of Energy Human Genome Program
Human Genome News Archive Edition
Human Genome News, July 1993; 5(2)
The Second International Workshop on Human Chromosome 9 was held April 18-20 in Chatham, Massachusetts. The meeting was attended by 66 participants, and 53 abstracts were presented.
Physical and Genetic Maps. Index marker and Centre d'Etude du Polymorphisme Humain consortium maps for the chromosome were discussed in detail. High-resolution mapping efforts resulting from disease-gene searches were described for several regions. These regions include 9p22 [near the interferon gene cluster, both A and B (IFN or IFNA)], site of melanoma-susceptibility and tumor-suppressor genes involved in leukemia, melanoma, lung cancer, and glioma pathogenesis; 9q22 (near D9S12), site of the ESS1 (multiple self-healing squamous epithelioma) and NBCCS (nevoid basal cell carcinoma syndrome) loci; and 9q34, which is near ABO (blood group locus), and site of one tuberous sclerosis locus (TSC1).
Disease Loci. Additional disease genes mapped to chromosome 9 in the past year include cartilage-hair hypoplasia (CHH) on 9p12-13; FACC (Fanconi's anemia, group C) on 9q22; and familial dysautonomia (DYS) on 9q31-32.
Resources. New chromosome 9 resources include an arrayed cosmid library [Pieter de Jong (Lawrence Livermore National Laboratory)], a YAC library [MaryKay McCormick (Los Alamos National Laboratory)], and an extensive collection of trapped exons [Alan Buckler (Massachusetts General Hospital)]. These resources complement existing radiation hybrid panels [Cynthia Jackson (Brown University and Rhode Island Hospital)] and translocation cell lines [Malcolm Ferguson-Smith (Cambridge University)].
A chromosome 9 anonymous ftp server has been established by John Attwood (University College, London;firstname.lastname@example.org). The address diamond.gene.ucl.ac.uk (220.127.116.11) may be used to download chromosome 9 workshop abstracts, figures, and reports (to be published later in Cytogenetics and Cell Genetics). An electronic mailing list has also been arranged for the chromosome 9 community.
[David J. Kwiatkowski, Brigham and Women's Hospital, Boston,
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Human Genome Program, U.S. Department of Energy, Human Genome News (v5n2).
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