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Human Genome News Archive Edition

Human Genome News, September 1993; 5(3)

Resources Available


HUGO Mouse Resources Database

The Human Genome Organization (HUGO) Mouse Resources Database has been mailed in hard copy to all HUGO members. The database, which was compiled by Mouse Committee Chairman Steve Brown, is designed to (1) provide global information on mouse genome mapping resources and projects not generally available through established outlets and (2) foster many new points of contact between human and mouse genetics communities. The database will be updated and circulated every 6 months.

The database is compiled on Hypercard, provided with most Macintosh computers. Information from each laboratory is contained on an individual card carrying a number of fields that cover different resource areas. Hypercard allows users to carry out a variety of functions, including searching for specific strings; printing available fields or subsets of fields in the chosen format; and even modifying the database to suit individual needs.

To receive a copy of the database on disk, send a letter or fax with all contact information to HUGO Europe; One Park Square West; London NW1 4LJ (+ 44/71-935-8085, Fax: -8341). To make corrections, additions, or new entries, contact Brown at the Department of Biochemistry and Molecular Genetics; St. Mary's Hospital Medical School; London W2 1PG; U.K. (+44/71-723-1252, ext. 5484; Fax: -706-3272; Internet: s.brown@sm.ic.ac.uk).


Genetic Mapping Directories, Files

The Cooperative Human Linkage Center (CHLC), directed by Jeffrey Murray, was established by the National Center for Human Genome Research in the fall of 1992 to develop high-heterozygosity genetic maps. CHLC has projects located at the University of Iowa, Fox Chase Cancer Center, Marshfield Medical Research Foundation, and Harvard Medical School.

The following directories and files are available from CHLC via anonymous FTP to ftp.chlc.org and through a CHLC Gopher Server addressed gopher.chlc.org.

  • chlc/newsletters: CHLC newsletters in plain text and postscript. [Volume 1(1) of CHLC Report was published in May. To subscribe to the hard copy version of the newsletter, contact CHLC Administration; #440 EMRB; University of Iowa; Iowa City, IA 52242.]
  • chlc/genotypes/tables: Tabular descriptions of marker systems in chromosome-specific data sets.
  • chlc/genotypes/typing: Chromosome-specific genotype sets in CRIMAP file format.
  • chlc/maps/framework: Framework maps of all markers currently mapped by CHLC (including markers from other sources).
  • chlc/maps/skeletal: Maps generated using stringent map-building algorithms.
  • chlc/markers/chlc: CHLC-produced marker data.
  • chlc/markers/marshfield: Marker data produced by Marshfield Medical Research Foundation.

Useful e-mail addresses include the following.

  • help@chlc.org: Answers from CHLC staff to questions about CHLC services.
  • info-server@chlc.org: Descriptive information about the CHLC project and data.
  • linkage-server@chlc.org: Server that will genetically map submitted markers using CHLC data sets.

Note: All CHLC postings will be presented via an appropriate BIOSCI newsgroup (currently BIOSCI/GENETIC-LINKAGE). Users with USENET news can access the newsgroup with this address: bionet.molbio.gene-linkage. Requests for adding or canceling e-mail subscriptions to BIOSCI should be sent to biosci@net.bio.net (Americas and Pacific Rim) or biosci@daresbury.ac.uk (Europe, Africa, and Central Asia).


Biotechnology Pharmaceuticals

Sales of pharmaceuticals derived from biotechnology research and development are expected to rise from $2.38 billion in 1992 to $9.2 billion by 2000, according to Biotechnology in the U.S. Pharmaceutical Industry, a new report from the Institute for Biotechnology Information. Institute Director Mark Dibner said, "There are two notable findings from our analysis. First, the increase is flat at 10 to 26% growth per year, not rising exponentially. Second, sales of these compounds will rise from 4.6% of U.S. drug and vaccine sales to just over 13% by 2000."

The special 400-page report contains details on 23 marketed drugs (for 31 indications) and 305 drugs and vaccines in clinical trial. This information was derived from numerous sources, including sales projections, market forecasts, estimated times of approval, and estimates of market penetration. Activities and affiliations are described for 71 sites of 41 pharmaceutical companies having biotechnology Rand D programs and for biotechnology firms with products on the market. Specific markets and sales are identified. [$595, 1993. Institute for Biotechnology Information; P.O. Box 13547; Research Triangle Park, NC 27709-3547 (919/549-8880, Fax: /990-9521).]


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The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v5n3).

Human Genome Project 1990–2003

The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.

Human Genome News

Published from 1989 until 2002, this newsletter facilitated HGP communication, helped prevent duplication of research effort, and informed persons interested in genome research.