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Human Genome News Archive Edition

Human Genome News, January 1994; 5(5)

Faster Linkage Analysis

The LINKAGE software package, which uses statistical analysis of pedigree data for locating genes, has been modified by Robert Cottingham (Baylor College of Medicine), Rama Idury (University of Southern California), and Alejandro Schaffer (Rice University) to speed up long linkage-analysis computations by roughly 10 times. Improvements were made in the combinatorial part of the code only. A paper describing the modifications appeared in the American Journal of Human Genetics [53(1) (July 1993)]. A Post-Script version of this paper and the improved code can be retrieved via ftp from a computer at BCM as decribed below (a PostScript printer is needed).

Information on compiling modified versions of the LINKAGE 5.1 general pedigree programs, which are written in C, is given in the README file (get Readme). Release of a future version with more improvements is expected. Monitor the bionet.molbio.gene-linkage newsgroup for updates.


FTP Instructions
(Italics indicate what to type)

  • ftp gc.bcm.tmc.edu
  • kiwi.imgen.bcm.tmc.edu user
  • foreign username: anonymous
  • password: userid@mailaddress
  • kiwi.imgen.bcm.tmc.edu cd linkage
  • kiwi.imgen.bcm.tmc.edu cd fastlink.51
  • kiwi.imgen.bcm.tmc.edu get paper.ps
  • transfer complete.
  • kiwi.imgen.bcm.tmc.edu exit

For help, contact Cottingham at bwc@bcm.tmc.edu.


HGMIS Staff

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The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v5n5).

Human Genome Project 1990–2003

The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.

Human Genome News

Published from 1989 until 2002, this newsletter facilitated HGP communication, helped prevent duplication of research effort, and informed persons interested in genome research.