Sponsored by the U.S. Department of Energy Human Genome Program
Human Genome News Archive Edition
Human Genome News, May 1994; 6(1)
Mouse Gene Loci Data Files. A group of servers has been set up at the University of Tennessee (UT), Memphis, from which data files on mouse loci, many from the 1992 and 1993 Chromosome Committee reports, can be downloaded (see addresses below). New data include map position information for Massachusetts Institute of Technology loci released in April. Chromosome-specific files can be downloaded in generic text format or as Excel or FileMaker Pro files.
The World Wide Web (WWW) server, accessible using Mosaic (from the National Center for Supercomputing Applications at the University of Illinois), is a repository of Map Manager files. These include data sets on the new Birkenmeier loci [Lucy Rowe and Ed Birkenmeier (Jackson Laboratory)], the Shionogi loci from the National Center for Cardiovascular Research, Japan [Ken Manly and Verne Chapman [Roswell Park Memorial Institute (RPMI)], Rosemary Elliott's (RPMI) new recombinant inbred data files in Map Manager format, and updates of the Portable Dictionary files.
All these servers require an Internet-connected computer. The WWW Mosaic program is the only known client for downloading Map Manager files. Map Manager, a Macintosh-only program written and supported by Manly, is accessible via ftp at mcbio.med.buffalo.edu. Users who have Map Manager data sets to make available over the Internet should e-mail the Map Manager files to firstname.lastname@example.org. All collaborators should agree to making files public before data are sent.
Portable Dictionary of the Mouse Genome. The Portable Dictionary of the Mouse Genome, a compact database for use on personal computers, contains information on over 12,000 mouse loci and on homologs in several other mammalian species, including human, rat, cat, cow, and pig. Key features are its compact size (less than 10 MB), network independence, and ability to convert to formats suitable for a wide variety of common programs. The dictionary includes DNA sequence accession numbers for over 1200 genes. Loci can be resorted rapidly by chromosomal position, type, human homology, or gene effect. The accessible, easily manipulated set of data has many uses, from a quick review of loci and gene nomenclature to the design of experiments and analysis of results. Updated versions of the Portable Dictionary of the Mouse Genome can be downloaded from the addresses above. The dictionary is also available on the January NCBI Data Repository CD-Rom disk.
[Contact for comments, corrections, and additions: Robert Williams; Department of Anatomy and Neurobiology; University of Tennessee; 875 Monroe Ave.; Memphis, TN 38163 (901/448-7018, Fax: -7193, Internet: email@example.com).]
SubmitData is a newly developed software program that allows fast and easy submissions to a particular database by merging a list of data records with a predefined template. SubmitData, which was developed in Smalltalk-80, generates appropriate forms from individual database protocol definitions and checks data values for conformance to the protocol. This capability makes the program readily adaptable to new or changing definitions.
SubmitData combines three functions: (1) template creation and editing, (2) data merging, and (3) data submission. The template editor presents a number of forms showing required and optional fields for constructing a valid data submission. The editor allows the user to choose from a controlled vocabulary when appropriate, checks entered values for agreement with type and range specifications, inserts default values, revises dates if necessary, and generates error messages. Column and reference variables can also be defined in the template (a column variable is a placeholder for the value in a column of the data record, and a reference variable allows references to other template fields). A finished template can be saved, printed, and modified to fit future submissions.
Another editor is used to specify the merging operation, and each variable in the submission template is associated with a column in a tab-delimited input file. Merging can be tested for accuracy and completeness. The final step names the input data file and merges each data record with the template. A dialogue at the end confirms the automatic transfer to a particular database. Once a template and merging operation have been defined, new data can be submitted in a single step.
The first version of SubmitData constructs submissions for GenBank using the same protocol as AUTHORIN, which can be edited and used for automatic bulk submissions. Submission to Genome Data Base is under development and will be available soon. For more information, contact Manfred Zorn (Lawrence Berkeley Laboratory, 510/486-5041, Internet: firstname.lastname@example.org or BITNET: mdzorn@lbl).
Numerous HGN articles are being reprinted in other publications, including the newsletters of various universities and disease-gene groups. HGMIS encourages readers to duplicate and reprint any part of HGN. Contacting HGMIS is not necessary, permission is not required, and no charge is made. When reprinting an article, please add a credit such as "Reprinted from the U.S. DOE-NIH newsletter Human Genome News. For a free subscription to HGN, contact Betty Mansfield at 615/576-6669 or email@example.com." Send us a copy of the publication, if possible.
The following three products of the European Molecular Biology Laboratory (EMBL) Data Library are freely available by ftp (ftp.embl-heidelberg.de), Gopher (gopher. embl-heidelberg.de), and WWW (www.embl-heidelberg. de). [Contact: EMBL Data Library; Postfach 10.2209; 69012 Heidelberg, Germany (Fax: +49/6221-387-519, Internet: firstname.lastname@example.org).]
MacPattern Fast Pattern and Block Searching: A computer program that helps researchers find putative biological functions for new protein sequences through a combination of algorithms. Fast and user friendly, MacPattern supports protein pattern searches using the PROSITE database, protein block searches with the BLOCKS database, and identification of statistically significant protein segments. It allows batch processing of sequences and automatic translation of nucleotide sequence data. Already in use by various genome projects worldwide, MacPattern is particularly suited for genome analysis and cDNA sequencing projects.
EMBL-Search: A database query-and-retrieval program for Macintosh systems. It enables easy construction of complex queries on EMBL, SWISS-PROT, PROSITE, EPD, and ENZYME databases as supplied on the EMBL CD-ROM, which also includes EMBL-Search. Full utilization of database cross-reference information allows easy movement between databases and exploration of related information. EMBL-Search can be particularly cost-effective because of its ability to run on a local computer network accessing a shared database CD-ROM [Internet: email@example.com].
Mail Server Utility (MSU): Simplifies the use of electronic mail servers for sequence analysis by helping users produce properly formatted requests with a simple menu interface. Service descriptions are defined in external control files, which can be changed with a normal text editor without affecting the main program. MSU, which runs on UNIX and OpenVMS platforms, is a highly flexible tool that allows easy modification, extension, and customization to suit individual requirements.
[Rainer Fuchs, EMBL Data Library]
The following books are available from the American Association for the Advancement of Science (AAAS): The Genetic Frontier: Ethics, Law, and Policy (catalog no. 93-27S), based on an invitational conference, consists of 15 original essays by experts in genetics, ethics, law, philosophy, and social science. Topics include privacy and confidentiality issues, genetic testing, property rights, family relationships, and social policies. [AAAS Press Books: P.O. Box 521; Dept. D3GT; Annapolis Junction, MD 20701 (800/222-7809, Fax: 301/206-9789).] Ethical and Legal Issues in Pedigree Research reports on an invitational conference at which participants, including researchers studying five different genetic disorders, discussed such issues as informed consent, subject recruitment and withdrawal, privacy and the control of genetic information, children as research subjects, the role of researchers and provision of clinical care, and publication practices. [Contact for ordering: Kamla Butaney; AAAS Directorate for Science and Policy Programs; 1333 H Street NW; Washington, DC 20005 (202/326-6792, Fax: /289-4950).]
Release Six of the Whitehead Institute-Massachusetts Institute of Technology Genome Center Genetic Map of the Mouse is now available. The map consists of randomly chosen simple sequence length polymorphisms (microsatellites) that can be analyzed using the polymerase chain reaction, as described in W. Dietrich et al., Genetics 131, 423-47 (1992).
Release Six contains 3752 markers that fall into 20 linkage groups spanning about 1400 cM with an average spacing of less than 0.5 cM. The map can be accessed via the following:
This project is ongoing, and new markers will be released at the beginning of each quarter. [Contact for questions and comments: Ert Dredge; Whitehead Institute Center for Genome Research; One Kendall Square; Bldg. 300, 5th Floor; Cambridge, MA 02139 (617/252-1922, Fax: -1902, Internet: firstname.lastname@example.org).]
A mouse genetic linkage map file can be generated via e-mail using a new map-drawing resource from the Mouse Genome Informatics Project at Jackson Laboratory. After a text file is e-mailed to the service, a postscript file is returned by e-mail. When sent to a postscript printer, this file will print a mouse genetic linkage map displaying loci at their relative positions along a chromosome.
Access to the program is accomplished in three steps:
The return e-mail message will be either a postscript file for printing the linkage map or a report of errors detected in the map request. Maps can be customized in a number of ways, and several variations in the data file can be used to create maps for different purposes.
A manuscript describing this service has been submitted to Mammalian Genome. For a copy of the paper, including example figures showing the file sent and the resulting map, contact Michelle Stanley (207/288-3371, ext 1421, Fax: -2516, Internet: email@example.com).
[Janan T. Epping and Michael Kosowsky, Jackson Laboratory]
A set of eight 60-min. videotapes is available for The Secret of Life, a series funded by NIH and DOE and shown last year on public television. The series explores how scientists' ability to decipher and manipulate genes will transform medicine and affect human lives. #3342. Tapes are also available separately. [Contact: Films for the Humanities & Sciences; P.O. Box 2053; Princeton, NJ 08543; (800/257-5126, Fax: 609/275-3767).]
HGMIS would like to be informed about informatics and educational resources freely available for use by genomics researchers and educators.
Please contact Human Genome News staff.
The fax number for George Kutukdjian at UNESCO is +33/1-4306-0772.
The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v6n1).
The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.
Published from 1989 until 2002, this newsletter facilitated HGP communication, helped prevent duplication of research effort, and informed persons interested in genome research.