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Human Genome News Archive Edition

Human Genome News, Vol.7, No.2, July-August, 1995

Biological Resources

Mapped Genomic Reagents Resource More than 3200 human BACs and 250 PACs are now available from the Mapped Genomic Reagents Resource. The DOE-funded resource is headed by Julie Korenberg (Cedars-Sinai Medical Center and University of California, Los Angeles) and represents a collaboration with the two groups generating BAC and PAC libraries [Melvin Simon (California Institute of Technology) and Pieter de Jong (Roswell Park Cancer Institute)]. The project aims to establish an ordered sequenceable array of human BACs as a set of stable genome reagents that ultimately will be integrated with other vectors for sequencing, gene isolation, and molecular cytogenetic markers. Plans are to provide 24,000 BACs rapidly and cost-effectively as molecular cytogenetic markers, stable vectors for genome mapping and sequencing, and nucleation sites for contig construction. The mapped clones have also been provided to Thomas Hudson (Massachusetts Institute of Technology Whitehead Institute) to establish STS assignments. Descriptions of the resource and associated database, reagent request form, and GIF illustrations of the genome-wide probe distribution can be found under "Integrated YAC/BAC/PAC Resource" http://www.csmc.edu/csri/korenberg/.

Coriell Cell Repositories The National Institute of General Medical Sciences Human Genetic Mutant Cell Repository is requesting submission of blood or lymphoblastoid cell cultures from probands with well-documented phenotypes representing a variety of familial complex genetic disorders. In addition to familial cancers, complex disorders being sought include multiple sclerosis, epilepsy, Parkinsonism, hypertension, atherosclerosis, long QT syndrome, osteoporosis, asthma, rheumatoid arthritis, nonsyndromic hearing loss, neural tube defects, congenital heart disease, cleft lip and palate, fetal alcohol syndrome, morbid obesity, psoriasis, glaucoma, macular degeneration, cataracts, migraine, lupus erythematosus, Crohn's disease and other inflammatory bowel diseases, autism, dyslexia, attention deficit disorder, and Tourette's syndrome.

The National Institute on Aging Cell Repository has available for distribution cell cultures from three of the extended pedigrees used to clone the AD3 gene for early-onset Alzheimer's disease. Affected and unaffected members of the Canadian Alzheimer's disease pedigree FAD1, the German FAD2, and the Italian FAD4 are included in the collection.[Coriell Cell Repositories (800/752-3805 or 609/757-4848, Fax: -9737)].


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Human Genome Program, U.S. Department of Energy, Human Genome News (v7n2).

Human Genome Project 1990–2003

The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.

Human Genome News

Published from 1989 until 2002, this newsletter facilitated HGP communication, helped prevent duplication of research effort, and informed persons interested in genome research.