BeBeryllium Research Symposium: Basic Mechanisms and Human Health
June 25- 26, 2002
National Library of Medicine, Bethesda, MD





 Session 1

 Session 2

 Session 3

 Session 4

 Session 5


Sponsored by
Department of Energy Seal
Office of Biological and Environmental Research,
The Department of Energy
in cooperation with


The National Institute for Occupational Safety and Health, and

National Jewish Medical and Research Center
The National Jewish Medical and Research Center



Welcome from the Planning Committee




Session 1. Immunopathology of Beryllium-Induced Granulomatous Disease 

  • Characterization of Beryllium-Specific Memory CD4+ T Cells in Patients with Chronic Beryllium Disease
    Andrew P. Fontenot, Scott J. Canavera, Laia Gharavi, Lee S. Newman, and Brian L. Kotzin

  • HLA-DP-Unrestricted TNF-a Release in Be-Stimulated
    PBMC from Berylliosis Patients

    Massimo Amicosante, Floriana Berretta, Alberto Franchi, Paola Rogliani, Chiara Dotti, Monica Losi, Raed Dweik, and Cesare Saltini

  • Design, Engineering and Production of Human Recombinant
    T Cell Receptor Ligands Derived from HLA-DP

    Gregory G. Burrows, Roberto Meza-Romero, Jeff Mooney, Justin W. Chang, Hans Peter Bachinger, and
    Jianya Huan

  • A Flow Cytometric Assay for Beryllium Sensitization: Screening and Mechanistic Applications
    A.J. Jabbour, R.A. Ponce, M.T. Rosato, T.J. Kavanagh, L.S. Newman, T.K. Takaro, and E.M. Faustman


Session 2. Pulmonary Signaling Pathways Activated by Beryllium

  • Beryllium Stimulates a Local Angiotensin System in Chronic Beryllium Disease
    T. Hendry-Hofer, A.F. Fontenot, E.A. Barker, M. Boguniewicz, L.S. Newman, and L.A. Maier

  • High Levels of Nitric Oxide (NO) in Exhaled Breath in Patients with Chronic Beryllium Disease
    R.A. Dweik, D. Laskowski, and S.C. Erzurum

  • Nitric Oxide (NO) Attenuation of Interferon Gamma (IFN-Gamma) Responses in Chronic Beryllium Disease (CBD): Evidence For Mechanisms Independent of Interleukin (IL)-18
    M.J. Thomassen, C. Farver, R.A. Dweik, D. Culver, B. Yen-Lieberman, M. Kavuru, and B.P. Barna

Session 3. Physico-Chemical Properties of Beryllium Metal and Alloys

  • Dosimetry of Beryllium in an Animal Model by Accelerator Mass Spectrometry
    M.L. Chiarappa-Zucca, R.C. Finkel, J.E. McAninch, R.E. Martinelli and K.W. Turteltaub

  • Identification of Non-Toxic Beryllium-Chelating Porphyrins and Method of Delivery to Mice in an Attempt to Reduce the Lung Beryllium (Be) Burden in Chronic Beryllium Disease (CBD)
    Jim Klostergaard and George P. Sakalosky

  • Surface Area of Respirable Beryllium Metal, Oxide, and Copper Alloy Aerosols and Implications for Assessment of Exposure Risk of Chronic Beryllium Disease
    A.B. Stefaniak, M.D. Hoover, R.M. Dickerson, E.J. Peterson, G.A. Day, P.N. Breysse, M.S. Kent, and R.C. Scripsick

  • Examining Beryllium Chemistry with Modern Analytical Techniques
    M. Sutton, S.R. Burastero, C. Mundy, and J. Quong


Session 4. Gene–Exposure Interactions

  • Functional TNF-a Promoter Polymorphisms Associated
    With Chronic Beryllium Disease and Beryllium-Induced
    L.A. Maier, R.T. Sawyer, T. Hendry-Hofer, C. Parsons, R. Bauer, D. McGrath, P. Lympany, R. duBois and L.S. Newman

  • Association of HLA Class II Markers and Beryllium Hypersensitivity and Disease: Reevaluation of Previously Published Data after 4-8 Years of Follow-up
    C. Saltini and M. Rossman

  • Electrostatic Potential on HLA-DP*1701 and HLA-DP*0401: Implications for Putative Mechanism of Chronic Beryllium Disease
    James A. Snyder, Ainsley Weston, Sally T. Tinkle, and Eugene Demchuk


Session 5. New Directions in Pulmonary Research

  • Cutaneous Application of Beryllium Salts and Oxide Particles Produces Beryllium-Specific Peripheral Sensitization in the C3H/HeOuJ Mice
    Sally Tinkle, James Antonini, Jenny Roberts, Rebecca Salmen, Karyn Depree, and Melanie Flint

  • In Vitro Transformation of Phagocytized Beryllium Oxide Particles in the Murine J774A.1 Cell
    G.A. Day, A.B. Stefaniak, M.D. Hoover, R.M. Dickerson, E.J. Peterson, N.A. Esmen, and R.C. Scripsick

  • The Mouse Deep Lung is Exposed to Respirable Particles Administered by Pharyngeal Aspiration
    A.F. Hubbs, G.V.S. Rao, M. Kashon, R. Salmen, L.A. Battelli, P. Willard, J. Antonini, D.N. Weissman, and S. Tinkle

  • Beryllium-Induced Macrophage Apoptosis in Chronic
    Beryllium Disease
    R.T. Sawyer, V.A. Fadok, L.A. Maier, L.A. Kittle, J.M. Routes, and L.S. Newman




Date Published: June 2002

Prepared for the
U.S. Department of Energy
Office of Science
Biological and Environmental Research Program
in cooperation with
National Institute for Occupational Safety and Health
National Jewish Medical and Research Center


Prepared by
Human Genome Management Information System
Oak Ridge National Laboratory
Oak Ridge, TN 37830


Managed by
UT‑Battelle, LLC
for the


Original Announcements: Agenda - Symposium Information - Speakers - Symposia - Hotel Accommodations - Registration Form - Abstract Submission Form - Poster (pdf, 1365 KB)