From Gene Expression Data to Gene Regulation

Alvis Brazma
EMBL Outstation -- Hinxton
European Bioinformatics Institute
Wellcome Trust Genome Campus
Hinxton, Cambridge CB10 1SD UK
telephone: +44-(0)1223 494658
fax: +44-(0)1223 494468
email: brazma@ebi.ac.uk
prestype: Platform
presenter: Alvis Brazma

Alvis Brazma, Jaak Vilo and Thomas Schlitt

DNA arrays are enabling researchers to make snapshots of gene expression levels for tens of thousands of genes at a given moment. This technology is already producing floods of valuable data, and the analysis and handling of these data is one of the most important and interesting problems of computational biology. We will discuss various informatics approaches to the analysis of DNA array data as well as our initiative to establish a public repository for these data. In particular we will discuss how these data can be used for finding putative regulatory signals in the genome and our approaches to the problem of reverse engineering of gene regulatory networks from gene expression data.



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