Beyond the Identification of Transcribed Sequences:
Functional, Evolutionary and Expression Analysis
12th International Workshop
October 25-28, 2002
Washington, DC


List of Abstracts * Speakers * Organizers * Authors * Original Announcement


Translational Control at the Interface Between the Genome and the Proteome

Matthias W. Hentze
EMBL, Heidelberg, D-69117 GERMANY
Telephone: +49-6221-387 501
Fax: +49-6221-387 518
Email: hentze@embl-heidelberg.de

Translation of messenger RNAs into polypeptides represents the interface between the genome and the proteome. Not surprisingly, this step in the gene expression pathway is frequently used for the regulation of biological responses. I will discuss principles by which structural features of mRNAs, regulatory RNA elements and RNA- binding proteins regulate protein synthesis. This will include findings that imply a new role of the poly(A) tail in the translation of messenger RNAs via IRESes (internal ribosome entry sequences), the understanding of an important switch in Drosophila development, and results from whole genome microarray analyses in yeast which suggest that signal-induced changes in the transcriptome are amplified at the translational level. These latter results unveil a novel, higher level of coordinated gene regulation, which we refer to as ‘potentiation’.



  Abstract List


List of Abstracts * Speakers * Organizers * Authors * Original Announcement


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