Beyond the Identification of Transcribed Sequences:
Functional, Evolutionary and Expression Analysis
12th International Workshop
October 25-28, 2002
Washington, DC


List of Abstracts * Speakers * Organizers * Authors * Original Announcement


Defining Functional Networks of RNA-Protein Interactions in the Nervous System

Kirk Jensen
The Rockefeller University, New York, 10021 USA
Telephone: (212) 327-7471
Fax: (212) 327-7109
Email: jensenk@mail.rockefeller.edu

The exploration of the role played by RNA binding proteins in the nervous system continues to be an exciting and productive area of research. Neuronal RNA binding proteins function as alternative splicing factors, regulate mRNA stability and protein translation, and can localize mRNA to dendrites; thus these proteins are key regulators of gene regulation in neurons. However, a major obstacle in the further understanding of how neuronal RNA binding proteins regulate gene expression has been the systematic identification of RNA substrates. We have developed a new methodology to comprehensively identify RNA-protein interactions that occur in vivo, and present here data using this technique to identify RNA targets of the Nova and Hu RNA binding protein families.



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List of Abstracts * Speakers * Organizers * Authors * Original Announcement


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