9th Annual Workshop, October 28-31, 1999
Co-sponsored by the U.S. Department of Energy
Finding gene boundaries on large contigs
SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania, USA
Sequence similarity is the most reliable tool available for gene structure prediction, but it is not infallible and, more importantly, is only available when a close homolog to the new gene is known. De novo gene prediction will play an especially important role in the next year, as the newly sequenced genome is scrutinized for medically important genes. The greatest limitation of the current generation of gene finders is in locating gene boundaries. We will discuss the extent of the problem and some progress towards a solution.