9th Annual Workshop, October 28-31, 1999
Co-sponsored by the U.S. Department of Energy
Towards the understanding of the possible impact of human endogenous retroviruses on evolutionary changes in genome transcription
Eugene D. Sverdlov
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
Human endogenous retroviruses (HERVs) likely representing footprints of ancient germ-cell retroviral infections occupy about 1% of the human genome. HERVs can influence genome regulation through expression of retroviral genes, genomic rearrangements following HERV integrations, or through the involvement of HERV LTRs in the regulation of gene expression.
Newly integrated HERVs might change the pattern of gene expression and therefore play a significant role in the evolution and divergence of primates. Comparative analysis of HERVs, HERV LTRs, neighboring genes, and their regulatory interplay in the human and ape genomes will help us to understand the impact of HERVs on the evolution and genome regulation. This report will present the data on:
These data as well as the results reported by other authors suggest the evolutionary significance of retroviral invasions in the primate genomes.
The research was partially supported by Russian National Human Genome Project and INTAS 96-1710 grants.