TRANSCRIPTOME 2002: From Functional Genomics to Systems Biology
March 10-13, 2002
Seattle, Washington, USA


Intelligent Bioinformatics Systems for Functional Genome Analysis

Daniel Gerlich, Martin Granzow, Julian Mattes, Wolfgang Tvarusko, and Roland Eils, Dr. Wolfgang Tvaruskoi (Intelligent Bioinformatics Systems) German Cancer Research Institute, Heidelberg, GERMANY

The BioFuture-Group "Intelligent Bioinformatics Systems" works on the development of bioinformatics systems for the interpretation of complex data generated by analytic processes in genetic diagnostics and cell biology research. In the recent years an increasing number of high troughput screening systems have been developed in molecular biology. While in the past decade most such techniques were devoted to sequencing the genome of humans and other organisms, more recently such techniques emerged to relating genomic structure to function. One example is the DNA chip technology, which allows the screening of the expression level of all genes in a given organism under different conditions in one experiment. With this technology the study of genetic effects of certain drugs has become possible thus paving the way for optimised design of new drugs and therapies. High throughput screening techniques generate a huge amount of data, which is difficult or even impossible to analyse without computer assistance. The development of fully automated computerized systems for the analysis of complex data in molecular biology is at the core of the group established in 2000 at the German Cancer Research Center (DKFZ Heidelberg). The research areas of major interest include:- Knowledge based data mining of molecular biological and clinical data for deciphering pathomechanisms in genetic diseaeses- Analysis and modelling/simulation of complex processes in cellular biology- Improving molecular cytogenetic dignostics by fully automated and highly sensitive image analysis systems.

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