TRANSCRIPTOME 2002: From Functional Genomics to Systems Biology
March 10-13, 2002
Seattle, Washington, USA


Comparative Analysis of TBX1 Genes and Their Promoters from Different Species

Ilya Ioshikhes, Jun Liao and Bernice Morrow, Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY

TBX1 gene plays a very important role in regulation of VCF syndrome and other diseases. In our work we present results of comparative bioinformatics sequence analysis of human TBX1 gene locus, in particular its promoter region, with syntenic mouse sequences. Conserved regions among the two species and their possible functional role are described. Results of sequence comparison of the human and mouse TBX1 genes to a closely related Drosophila T-box gene are also represented.

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