TRANSCRIPTOME 2002: From Functional Genomics to Systems
Molecular Genetic Profiling of Gleason Grade 4/5 Prostate Cancers Versus Benign Prostatic Hyperplasia
Mamatha Mahadevappa1, Zhaomei Zhang1, Mitchell C. Caldwell2, Zuxiong Chen2, Zhenbin Fan2, John E. McNeal2, Rosalie Nolley2, Thomas A. Stamey2, Janet A. Warrington1, 1Health Management Research, Affymetrix Inc., Santa Clara, CA, 2Department of Urology, Stanford University School of Medicine, Stanford, CA
Prostate cancer (PC) is one of the most common causes of cancer death among American men. Serum prostate-specific antigen (PSA) between 2-10 ng/ml has been widely used in the U.S. as a marker for PC. Serum PSA is largely related to benign prostatic hyperplasia (BPH), but correlates poorly with PC curative outcome at PSA (2-10 ng/ml). Gene expression characterization of grade 4/5 cancers could aid in the development of new PC serum markers. We compared the results of large-scale gene expression monitoring from 9 Gleason grade 4/5 cancers to 8 BPH. Hierarchical clustering separated two groups. 86 candidates were identified with p<0.0005. The candidates included genes previously associated with PC, e.g. hepsin, prostate-specific membrane antigen and prostate differentiation factor, as well as genes associated with oncogenesis, tumor suppression, transcription, signal transduction and apoptosis. A number of new candidates are presented as possibilities for further study.
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