cDNA Sequencing


Workshops on Complete cDNA Sequencing

Within the DOE Human Genome Program, support began in 1990 for high-throughput analyses of cDNAs, the sturdy representatives of the cell's fragile messenger RNAs (mRNAs) for gene expression.  In 1994 I.M.A.G.E (http://image.llnl.gov/) was founded to coordinate worldwide, public-sector efforts in cDNA analyses. For a few years, most cDNA sequencing was used to catalogue cDNAs by short sequence reads called expressed sequence tags (ESTs).  In the fall of 1996, several research teams worldwide announced plans for complete sequencing of cDNAs.

The following spring, a series of international cDNA workshops began. Building on the Integrated Molecular Analysis of Genome Expression (I.M.A.G.E.) consortium, the workshops' objectives were to extend the infrastructure I.M.A.G.E. has provided since 1994 to the challenges of complete cDNA sequencing. The workshops are listed below.

H-Invitational Annotation Jamboree (H-Invit 1)- August 25-September 3, 2002
Experts in functional annotation of genes and proteins were invited from all over the world to participate. The goal was to deeply annotate the whole world collection of genes, represented as their full length transcripts. It was supported by several participant countries and hosted at the Japan Biological Information Research Center (JBIRC), Odaiba, Tokyo

A popular science article on I.M.A.G.E. is in The Scientist, 13(4), February 15, 1999 with an update from EuroImage.


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Please send questions or comments to martinsa@ornl.gov