Sponsored by the U.S. Department of Energy Human Genome Program
Human Genome News, Nov. 1994; 6(4):2
Baylor College of Medicine (BCM)
BAYLOR COLLEGE OF MEDICINE (BCM)
- (NIH, established 1990)
- C. THOMAS CASKEY, Director
- David L. Nelson, Associate Director
- CONTACTS: Sandra McMurtry, Administrator (713/798-6524, Fax: -5386, mcmurtry@bcm.tmc.edu) or David Nelson (-3122; nelson@bcm.tmc.edu); BCM; One Baylor Plaza; Houston, TX 77030-3498.
OTHER KEY RESEARCHERS
- Antonio Baldini
- A. Craig Chinault
- Robert W. Cottingham, Jr.
- Richard A. Gibbs
- Gail E. Herman
- Charles B. Lawrence
- Cheng Chi Lee
- James R. Lupski
- John M. Shumaker
- Randall F. Smith
- Huda Y. Zoghbi
MAJOR GOALS
- Six core facilities provide support for independently funded physical mapping and positional cloning projects and development of technology, with emphasis on human chromosomes 6, 15, 17, and X and the mouse X chromosome.
MAJOR ACCOMPLISHMENTS
- Identification of several new disease loci, including Fragile X syndrome, myotonic dystrophy (DM), Charcot-Marie-Tooth disease, Kallman syndrome, glycerol kinase deficiency, Miller-Dieker lissencephaly, Lowe syndrome, and spinocerebellar ataxia type1.
- Identification of >2000 yeast artificial chromosome clones by polymerase chain reaction screening for target chromosomes.
- Assembly of contigs in target regions (many contigs >1 Mb from X, 17, 6, and 15).
- Development of methods for yeast artificial chromosome characterization and contig assembly.
- Development of Genome Data Base-Lite and a library screening and clone characterization database capable of periodic automatic submission to Genome Data Base.
- Completion of moderate-scale sequencing projects encompassing over 200 kb of human DNA from the X and other chromosomes (including the genes for Duchenne muscular dystrophy, candidate gene for X-inactivation center, Fragile X locus, and DM).
- Establishment of several hundred cell lines from patients with chromosome-linked disorders.
- Assembly of a 35-Mb contig in yeast artificial chromosomes for Xp21-ter.
- Development of a Mosaic browser for integrated yeast artificial chromosome data scanning.
AVAILABLE RESOURCES
- Total human yeast artificial chromosome libraries (Centre d'Etude du Polymorphisme Humain and Wash. Univ.].
- Chromosome X yeast artificial chromosome libraries (BCM and CHOP).
- Chromosome 17 and X cosmid libraries (LANL and LLNL).
- Screening service for chromosome 17p.
- Total mouse yeast artificial chromosome libraries (St. Mary's and Imperial Cancer Research Fund). DNA pools available for multistep polymerase chain reaction screening (yaclab@bcm.tcm.edu).
- Numerous patient cell lines and chromosome mapping cell panels for 6, 17, and X (hybrids, deletions, etc.).
- Sequence tagged sites and yeast artificial chromosomes for many loci on target chromosomes.
- Database software.
- NCHGR predoctoral training grant (Chinault).
- Quarterly newsletter.
HGMIS staff
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The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v6n4).
