Sponsored by the U.S. Department of Energy Human Genome Program
Human Genome News, Nov. 1994; 6(4):10
University of Utah
UNIVERSITY OF UTAH (UU)
- (NIH, established 1990)
- RAYMOND F. GESTELAND and ROBERT B. WEISS, Directors
- CONTACT: Gesteland (801/581-5190, Fax: /585-3910, rayg@gene1.med.utah.edu); UU; 6160 Eccles Genetics Bldg.; Salt Lake City, UT 84112.
OTHER KEY RESEARCHERS
- Jeff Botkin
- Peter Cartwright
- Mark Leppert
- Harold Swerdlow
MAJOR GOALS
- Development of resources and technologies for sequencing and mapping, including (1) organized front-end strategies for large sequencing projects; (2) DNA sequencing technology, including capillary and multiplex approaches; (3) informatics tools for automation of large-scale sequencing and for distributive database searches; (4) pilot large-scale sequencing; and (5) automated genotyping technology.
MAJOR ACCOMPLISHMENTS
- Development of a sensitive fluorogenic assay suitable for DNA detection on membranes; an automated chamber for unattended, sequential probing of multiplexed DNA sequencing patterns, including on-board image acquisition and base calling; magnetic bead technology for DNA preparation; transposon system for ordered sequencing of large fragments in the multiplex system; efficient multiplex method for large-scale genotyping; pilot-scale sequencing of human and mouse genomic regions; informatics tools for automating sequencing systems, transposon mapping, and database management searching; 12 mapping projects in the visitors' laboratory; and ethical, legal, and social issues seminars and projects.
AVAILABLE RESOURCES
- Transposon front-end reagents for sequencing.
- Mapping reagents and software.
- Multiplex sequencing protocols.
- URL: http://www-genetics.med.utah.edu
HGMIS staff
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The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v6n4).
