Sponsored by the U.S. Department of Energy Human Genome Program
Human Genome News, Nov. 1994; 6(4):12
Washington University School of Medicine
- WASHINGTON UNIVERSITY SCHOOL OF MEDICINE (WUSM)
GENOME SEQUENCING CENTER
- (NIH, established 1993)
- ROBERT H. WATERSTON, Director
- CONTACT: Paula Kassos, Administrator (314/286-1802, Fax: -1810, email@example.com); WUSM, Box 8501; 4444 Forest Park Blvd.; St. Louis, MO 63108.
- OTHER KEY RESEARCHERS
- Warren R. Gish
- LaDeana Hillier
- H. Mark Johnston
- Elaine R. Mardis
- David J. States
- Mark Vaudin
- Richard K. Wilson
- C. elegans Sequencing Collaborators:
- Sanger Centre (Medical Research Council, U.K.), John Sulston, Director.
- Contact: Jane Rogers, Administrator (+44-223/834938, Fax: /494919, firstname.lastname@example.org); Sanger Centre; Hinxton Park; Hinxton, Cambridge; UK CB10 1RQ.
- Other Key Researchers (Sanger Centre):
- Mary Berks
- Alan Coulson
- Simon Dear
- Richard Durbin
- Karen Thomas
- Other Collaborators:
- Philip Green (Univ. of Wash., Seattle)
- Roger Staden [MRC Laboratory of Molecular Biology (Cambridge, U.K.)]
- Jean Thierry-Mieg [Centre National de la Recherche Scientifique (Montpellier, France)]
- Complete determination by 1998 of genomic sequence (100 Mb) of the nematode C. elegans (with the Sanger Centre).
- Contribution to the rapid completion of the yeast S. cerevisiae genome Sequence with production of 2 to 3 Mb in 2 years.
- Development of technology and software for efficient large-scale genome sequencing.
- Completion of 8 Mb of nematode genomic sequence, containing about 1500 predicted genes (with the Sanger Centre).
- Completion of 1 Mb of yeast genomic sequence, including the complete sequence of chromosome VIII.
- Adaptation of methods to human genomic sequencing and application to human 16p21 cosmids.
- Development and implementation of the object-oriented database ACEDB to provide the sequence and physical map in the context of other information available for the nematode (with Durbin and Thierry-Mieg).
- Improvements in the Staden assembly-editing package (xbap and xgap); scripts to automate data transfer, handling, and analysis with improved data tracking; improved base calling and development of alternative assembly methods (with Green and Thierry-Mieg).
- Development of GENEFINDER, a program that accurately and rapidly predicts genes in nematode genomic DNA.
- Nearly complete C. elegans clonal physical map with cosmid and yeast artificial chromosome clones.
- Nearly complete S. cerevisiae clonal physical map, with cosmid and lambda clones.
- 1500 sequence-tagged and mapped cDNA clones.
- Software packages, including ACEDB, GENEFINDER, xbap/xgap, oligoselection, data tracking, and processing suites.
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The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v6n4).