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In this issue...
In the News
Ethical, Legal, and Social Issues and Educational Resources
Genetics in Medicine
Web, Other Resources, Publications
Meeting Calendars & Acronyms
The National Center for Biotechnology Information (NCBI) Web site links to sequences from unfinished microbial genomes for BLAST searching. These unfinished sequences, which are not yet in GenBank nor accessible via Entrez, also can be retrieved from their associated sequencing centers by ftp or Web. The 18 finished microbial genomes are searchable by Entrez via the NCBI site.
In September 1998, The Institute for Genomic Research (TIGR) announced the release of more than 1.9 Mb of genome sequence from Chlorobium tepidum, a photosynthetic gram-negative bacterium. The TIGR program, supported by DOE, has reached 3 coverage in the random-sequencing phase. The photosynthetic C. tepidum may play an important role in the earth's overall cycle of carbon use.
Microbial-Genomes is a newsgroup for the discussion of microbial (bacterial, archaeal, and small eukaryotic) genomes. To subscribe, email firstname.lastname@example.org, and send the command subscribe microbial-genomes as the only text in the body of a message.
The May-June 1998 issue of ScienceWatch, a publication of the Philadelphia-based Institute for Scientific Information, noted that the paper describing the complete genomic sequence of the 1.7-Mb archaeon Methanococcus jannaschii was the fifth most-cited paper in biology for the first 2 months of 1998. The paper, by C.J. Bult and others at The Institute for Genomic Research, confirmed the existence of a third kingdom of life on earth when it appeared in 1996 in Science (273, 1058). At the time of publication, only about one-third of the 1700 genes in M. jannaschii were found to resemble known genes, and the other two-thirds were completely novel to biology. This research was supported by the DOE Microbial Genome Program.
The Genome Information Broker (GIB) now includes 18 microbial genomes that have been sequenced completely and released from DDBJ, EMBL, and GenBank databases. GIB information includes the numbers and names of clones, open reading frames and genes, and sequences. Results are represented in interactive graphics and tables.
Web sites at the University of Illinois at Urbana-Champaign present
The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v10n1-2).
The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.