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Because molecular shape often provides clues to function in biological systems, obtaining a detailed knowledge of structure can help elucidate the basic principles of cell and organism function and the role of faulty structures in disease. A broad collection of structural data will provide valuable information beyond that available from individual structures and will have applications in the life sciences, biotechnology, and medicine.
Key advances making structural genomics research possible include the availability of synchrotrons and high-field NMR (nuclear magnetic resonance) instruments; the MAD (multiwavelength anomalous diffraction) method of phase determination; high-throughput cloning and recombinant expression; a flood of information from genome sequencing projects; and bioinformatics methods for protein-fold assignment, model building, and function prediction.
The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v11n3-4).
The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.