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Human Genome News Archive Edition

Human Genome News, January 1992; 3(5)

Barber Named Computational Biologist at DOE

Ann M. Barber recently joined the Human Genome Program staff of the DOE Office of Health and Environmental Research (OHER) in Washington, D.C., where her responsibilities as Computational Biologist will encompass a wide range of challenges in genome informatics.

In 1974 Barber received both her B.S. and M.S. mathematics degrees from Stanford University. She conducted image-processing research and worked in medical informatics before entering Northwestern University Medical School, from which she received her M.D. degree in 1981. After a 3-year residency in internal medicine, Barber served as Medical Staff Fellow at the NIH National Cancer Institute (NCI) in Bethesda, Maryland; her research years were spent at the NCI Laboratory of Mathematical Biology, where she became Senior Staff Fellow in 1987.

During 6 years at the NCI Supercomputer Center, Barber developed models and theories on DNA-protein interactions, created Unix/C software for aligning multiple sequences, and tested her hypotheses with molecular biology benchwork. Her SequenceEditingAligner, distributed internationally, helps find commonalities between different genes or species in hundreds of nucleic acid or protein sequences. Her work in DNA-protein interactions has revealed a new structural class of catabolite gene activator protein (CAP) DNA binding sites.

Barber's tasks at OHER include establishing goals and objectives of computer applications in the DOE Human Genome Program, promoting networking within the genome community for better interagency and international communication, and developing computational resources and techniques to elucidate biological structures and establish structure-function relationships.

Barber represents OHER at Protein Data Bank meetings and on the following groups: Genome Data Base Coordinating Committee, Energy Research Network Advisory Committee, GenBank® Advisors Committee, and GenBank Sponsors Forum. She is a member of OHER Structural Biology Task Group and the Human Genome Task Group.

Contact information: 301/903-9817, FTS 233-9817


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Human Genome Program, U.S. Department of Energy, Human Genome News (v3n5).

Human Genome Project 1990–2003

The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.

Human Genome News

Published from 1989 until 2002, this newsletter facilitated HGP communication, helped prevent duplication of research effort, and informed persons interested in genome research.