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Human Genome News Archive Edition

Human Genome News, November 1992; 4(4)

R&D 100 Award for GRAIL

The Gene Recognition and Analysis Internet Link (GRAIL) developed by Oak Ridge National Laboratory (ORNL) researchers has received an R&D 100 award from R&D Magazine as one of the 100 top new technologies for 1992. GRAIL, which was developed by Edward Uberbacher, Reinhold Mann, and Richard Mural, is a neural network that uses machine learning to identify exons, the instruction-giving sequence regions of genes. Each year inventors are honored at an awards dinner at the Museum of Science and Industry in Chicago, and the winning technologies are displayed there for a month.

Distinguishing between exons and introns (DNA that has little or unknown useful information) has been a very slow and labor-intensive task. To speed this process, investigators first obtained sequences from a DNA sequence database and assembled sets of them to train the neural network to recognize patterns. Users worldwide can now e-mail DNA sequence files to the system and have the analysis returned automatically by e-mail.

GRAIL contact:

  • Ed Uberbacher
    BITNET: ube@ornlstc.bitnet


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The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v4n4).

Human Genome Project 1990–2003

The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.

Human Genome News

Published from 1989 until 2002, this newsletter facilitated HGP communication, helped prevent duplication of research effort, and informed persons interested in genome research.