Sponsored by the U.S. Department of Energy Human Genome Program
Human Genome News, March 1993; 4(6)
GENOME CENTER:
Baylor College of Medicine
(NIH; established 1990)
DIRECTORS:
C. Thomas Caskey
Andrea Ballabio and David L. Nelson, Associate Directors
CONTACTS:
Sandra McMurtry, Administrator
(713/798-6524, Fax: -5386)
David Nelson
(-3122; nelson@bcm.tmc.edu)
Baylor College of Medicine
Institute for Molecular Genetics
One Baylor Plaza
Houston, TX 77030-3498.
OTHER KEY RESEARCHERS:
Antonio Baldini, Charles Lawrence, A. Craig Chinault, Edward McCabe, Richard A. Gibbs
MAJOR GOALS:
Six core facilities provide support for independently funded physical mapping and positional cloning projects and development of technology, with emphasis on chromosomes 6, 15, 17, and X.
MAJOR ACCOMPLISHMENTS:
- Identification of several new disease loci, including Fragile X syndrome, DM, CMT disease, Kallman syndrome, and Lowe syndrome.
- Identification of >1000 YAC clones by PCR screening for target chromosomes.
- Assembly of contigs in target regions (many contigs >1 Mb from X, 17, 6, and 15).
- Development of methods for YAC characterization and contig assembly.
- Development of GDB Lite, a database incorporating GDB chromosome data in a user-friendly format. Also development of a library screening and clone characterization database capable of periodic automatic submission to GDB.
- Completion of moderate-scale sequencing projects encompassing over 200 kb of human DNA from the X and other chromosomes (including the genes for DMD, XIST, FRAXA, and DM).
- Establishment of several hundred cell lines from patients with chromosome-linked disorders.
- Production of detailed physical map of Xpter-Xp21.
AVAILABLE RESOURCES:
- Total human YAC libraries (CEPH and Washington Univ.).
- Chromosome X YAC libraries (Baylor and CHOP).
- Chromosome 17 and X cosmid libraries (LANL, LLNL).
- Screening service for chromosome 17p.
- Numerous patient cell lines and chromosome mapping cell panels for 6, 17, and X (hybrids, deletions, etc.).
- STSs and YACs for many loci on target chromosomes.
- Database software.
- NCHGR predoctoral training grant (Chinault).
Genome Center Acronym List
HGMIS Staff
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