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Human Genome News Archive Edition

Human Genome News, March 1993; 4(6)


Stanford University

(NIH; established 1990 at UCSF; relocated March 1993)

Richard M. Myers, Director
David R. Cox, Codirector

Cristina Estebanez (415/812-1915, Fax: -1916;
Richard Goold (-1920, Fax: -1916;
Stanford University
Human Genome Mapping Center
Department of Genetics
855 California Avenue
Stanford, CA 94304

Sidney Cowles, Richard Goold, Cynthia Keleher, Laura Stuve


  • Generation of high-resolution human chromosome 4 maps (radiation hybrid and clone) and achievement of complete chromosome coverage in sequence-ready clones.
  • Construction of a radiation hybrid map of the entire human genome with 5000 to 10,000 STSs at an average resolution of 0.5 to 1.0 Mb.
  • Development of technologies for rapid sequencing of selected 2-Mb segments of human chromosome 4.


  • Completion of over 1100 STSs from human chromosome 4, including 170 SSRs and 50 known genes. Localized (by PCR) 945 of the STSs within 9 bins defined by well-characterized breakpoints from translocation chromosomes.
  • Construction of a radiation hybrid map that includes 672 of the STSs, providing a comprehensive map at a resolution of 0.5 Mb and a framework map at a resolution of 1.0 Mb.
  • Isolation of 775 YACs (average insert size, 400 kb; from CEPH Mark I YAC library) from 404 of the STSs.


  • Cosmid and plasmid clones for over 1000 chromosome 4 loci.
  • Primer and complete STS sequences (average size of each STS, 300 bp), with PCR conditions of 1100 STSs.
  • Radiation hybrids.
  • YAC clones for 404 chromosome 4 loci.
  • YAC libraries.
  • Educational resources, including tours of the center and lectures on genome science for students and lay groups.

Genome Centers Acronym List


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The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v4n6).

Human Genome Project 1990–2003

The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.

Human Genome News

Published from 1989 until 2002, this newsletter facilitated HGP communication, helped prevent duplication of research effort, and informed persons interested in genome research.