Human Genome News, March 1993; 4(6)

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Human Genome News, March 1993; 4(6)

GENOME CENTER:

University of Utah

(NIH; established 1990)

DIRECTORS:
Raymond F. Gesteland and Ray White

CONTACT:
Raymond Gesteland (801/581-5190, Fax: /585-3910; rayg@genetcs.med.utah.edu)
University of Utah
Department of Human Genetics
6160 Eccles Genetics Building
Salt Lake City, UT 84112

OTHER KEY RESEARCHERS:
Hans Albertson, Peter Cartwright, Mark Leppert, Harold Swerdlow, Robert Weiss

MAJOR GOALS:

Development of resources and technologies for mapping and sequencing, including (1) polymorphic DNA markers for human chromosomes; (2) automated technology for genotyping; (3) organized front-end strategies for large sequencing projects; (4) DNA sequencing technology, including capillary and multiplex approaches; (5) informatics tools to integrate chromosome maps, pedigree data, and large sequence databases; and (6) informatics systems for distributive database searches.
Pilot projects for assessment of new sequencing technology.

MAJOR ACCOMPLISHMENTS:

Generation of > 1200 STSs (mapped 1052, of which 650 are SSRs). Construction of a chromosome 17 map with 72 markers spaced an average of 4.2 cM apart.
Development of (1) a transposon system for breaking up large DNA fragments into ordered sets for large-scale sequencing projects; (2) capillary gel electrophoresis method for sequencing DNA; and (3) instrumentation for efficient, automated implementation of multiplex technology for large-scale sequencing. Sequenced 100 kb of the neurofibromatosis gene as a pilot test of the transposon front-end system.
Developments for informatics, including (1) pedigree editor; (2) system for implementation of transposon mapping system; (3) a new algorithm for automated calling of DNA sequence from autoradiograms; and (4) dedicated parallel architecture chips for very fast DNA sequence comparisons.
Establishment of an ELSI program for community outreach.

AVAILABLE RESOURCES:

Reagents and sequences for mapping.
Genome technology workshop scheduled for June 1993.
Visitor laboratory available to give visiting scientists access to biological and technological laboratory resources.

Genome Centers Acronym List

HGMIS Staff

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The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v4n6).

Human Genome Project 1990–2003

The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.