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1990–2003

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Human Genome News, July 1993; 5(2)

Repetitive-Element Searching

Pythia Version 1.5 is available for analysis of repetitive elements in human DNA. Pythia performs the following three DNA sequence analysis tasks.

  • Identification of DNA element repetitions by comparing DNA sequences with the updated reference collection of repetitive elements maintained by Jerzy Jurka (Linus Pauling Institute) [see HGN 4(2), 5 (July 1992)]. The repetitive regions are recognized using the algorithmic significance method of Aleksander Milosavljevic (Argonne National Laboratory) [Proc. First Int. Conf. Intelligent Syst. Mol. Biol. (1993), in press].
  • Identification of subfamily membership of Alu sequences by aligning DNA sequences against the Alu consensus and by identifying bases in a set of positions that are diagnostic for individual Alu subfamilies [J. Mol. Evol. 32, 105-21 (1991)]. The subfamilies were originally reconstructed using the minimal-length-encoding method [Mach. Learn. J. 12(1-3), 69-87 (1993)].
  • Identification of simple DNA regions consisting of tandem repeats and similar repetitive patterns. The regions are recognized using the algorithmic-significance method [Comput. Appl. Biosci. 9(4) (1993), in press].

The programs can be accessed via electronic mail or obtained in Sun Sparcstation executable form (compiled under Sun OS 4.1.2). For instructions on using the e-mail server, send the word help in the subject line to the Internet address pythia@anl.gov; to obtain the software, type software in the subject line.

Aleksandar Milosavljevic
Argonne National Laboratory
(708/252-7860, Fax: -3387, Internet: milosav@anl.gov)

Jerzy Jurka
Linus Pauling Institute
(415/327-4864, Internet: jurka@jmullins.stanford.edu)

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The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v5n2).

Human Genome Project 1990–2003

The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.

Human Genome News

Published from 1989 until 2002, this newsletter facilitated HGP communication, helped prevent duplication of research effort, and informed persons interested in genome research.