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The Draft Sequence Consortium

The consortium's goal is to produce a working draft covering at least 90 percent of human genome sequence within one year. The sequencing strategy involves determination of the sequence from mapped segments of DNA from known locations in the genome. These data are then assembled in overlapping stretches that reflect the accurate orientation of the DNA in the genome. In plans drawn up in the fall of 1998, Genome Project leaders projected completing the working draft by December 2001. The new consortium goal advances this timetable by more than a year and a half. The working draft will then serve as the scaffold for the painstaking but critical work of finishing, which involves closing gaps and correcting errors, leading to completion of the permanent high-quality, human DNA sequence by 2003 at the latest.

The five largest sequencing laboratories have joined together in a tightly knit collaboration with weekly meetings, shared materials, and shared protocols. The NHGRI funded laboratories will be responsible for producing approximately 60 percent of working draft sequence. DOE's Joint Genome Institute and the Sanger Centre will be responsible for producing approximately 10 percent and 33 percent respectively. "As one of the founders of the Human Genome Project, the Department of Energy is gratified to see the launch of the final stage of this project that promises such benefit to humanity," said Under Secretary of Energy Ernest Moniz.

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Last modified: Wednesday, October 22, 2003

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