Beyond the Identification of Transcribed Sequences: Functional and Expression Analysis

10th Annual Workshop

October 28-31, 2000
Heidelberg, Germany

Co-sponsored by the US Department of Energy

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Meeting Objective

The 2000 Workshop is the tenth in this series. Originally designed to discuss methods for isolation and verification of transcribed sequences from the mammalian genome, progress in this and other areas has prompted significant broadening of this focus.

Topics to be discussed include but are not limited to: mammalian gene and genome organization as determined from the construction of transcriptional maps and genomic sequence analysis; expression analysis of novel mammalian genes; analysis of genomic sequence, including gene and regulatory sequence prediction and verification, and annotation for public databases; expression and mutation analysis, and comparative mapping in model organisms (e.g. yeast, C. elegans, drosophila, zebrafish, pufferfish, chicken, mouse, rat); construction and analysis of transgenic organisms; novel approaches for functional analysis of transcribed sequences; construction of full length and 5' specific cDNA libraries; database construction, management and use in expression and functional analysis; and analysis of protein structure and function.

Functional determinations promise to be more challenging than transcript identification and even genomic sequencing. Methods for and results of mutational analysis in model organisms, including mouse, rat, zebrafish, drosophila, C.elegans and yeast, are informative and are now often being scaled up for genome wide applications. Evolutionary approaches, including cross species sequence comparisons and studies on features of genome organization, evolution and conserved synteny are critical. Non-coding sequences, in DNA and RNA, are fraught with possibilities for regulation of expression and structural features.

The aim of this workshop is to bring together investigators interested in these, and related topics, for informal presentations and discussions. The format is designed to facilitate the exchange of ideas across disciplines, and to aid in the forming of new interactions and new collaborations.


  • Katheleen Gardiner, Eleanor Roosevelt Institute, Denver, CO USA
  • Bernard Korn, German Cancer Research Center, Heidelberg, Germany
  • Richard Mural, Celera Genomics, Rockville, MD, USA
  • Sherman Weissman, Yale University, New Haven, CT, USA
  • Thomas Werner, Institute for Saeugertiergenetik, Oberschleissheim, Germany

Highlights from the 1999 Workshop

(See "Report of the 9th International Workshop on the Identification of Transcribed Sequences, 1999", Cytogenetics and Cell Genetics, Volume 88, Pages 1-10, 2000)

For Questions or Additional Information, contact:

Katheleen Gardiner,
Tel: 303-336-5652

Bernhard Korn,
Tel. 49-6221-42-4700

Peggy Woodson,
Tel: 303-336-5612

Original Announcement


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