TRANSCRIPTOME 2002: From Functional Genomics to Systems Biology
March 10-13, 2002
Seattle, Washington, USA


Whole Genome Functional Analysis and Metabolic Pathway of Zymomonas mobilis

Sang-Ho Park1, Ki-Nam Heo1, Hyun-Seok Parkv, Jeong-Sun Seo1, 2, 1Macrogen Co., Seoul, South Korea, 2Seoul National University, Seoul, SOUTH KOREA

Recent advances in genomics, transcriptomics, metabolomics and bioinformatics have led to a growing interest in using whole genome sequence data to reconstruct precise metabolic pathways in microbials for industry and pharmaceutics.  Zymomonas mobilis was chosen as a model organism for the study of microbials, and the entire genome has been sequenced using a random shotgun approach.  This bacterium is a facultative anaerobic Gram-negative rod with a high level of ethanol fermentation through the Entner-Doudoroff pathway. We have completed whole genome assembly and initial prediction of protein coding regions and functions by utilizing several different tactics. To confirm gene expression and functions, we are developing an integrated functional genomics tool using the initial annotation, DNA Microarray data, protein profiles, and metabolite profiles. We are also developing algorithms for promoter prediction in the whole genome. Our goal is to develop effective tools for metabolic pathway mapping and its application in microbial chemical production.

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