Archive Site Provided for Historical Purposes
The Human Genome Project (HGP) was completed in 2003. One key research area was bioinformatics. Without the annotation provided via bioinformatics, the information gleaned from the HGP is not very useful. This page details HGP bioinformatics research.
Informatics is the creation, development, and operation of databases and other computing tools to collect, organize, and interpret data.
Continued investment in current and new databases and analytical tools is critical to the future usefulness of HGP data. Databases must adapt to the evolving needs of the scientific community and must allow queries to be answered easily. Planners suggested developing a human genome database, analogous to model organism databases, that links to phenotypic information. Also envisioned were databases and analytical tools for studying the expanding body of gene-expression and functional data, for modeling complex biological networks and interactions, and for collecting and analyzing sequence-variation data.
Bioinformatics and Computational Biology
Text adapted from F. Collins, Ari Patrinos, et al., "New Goals for the U.S. Human Genome Project: 1998–2003," Science 282: 682-689 (1998). For a more detailed explanation of informatics, see the U.S. DOE Primer on Molecular Genetics. For more on the project's goals, see the HGP Goals page.
The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.