Archive Site Provided for Historical Purposes
The April 11, 2003 issue of Science and the April 24, 2003 issue of Nature (see also: special web focus) presented a special collection of news, viewpoints, and other articles to celebrate the 50th anniversary of one of the signpost events of modern biology -- the publication of the structure of DNA -- and the new directions in molecular biology that the double-helix discovery has marked out in the subsequent half-century.
The first analyses of the working draft human genome sequence were reported in the February 16, 2001 issue of Science and February 15, 2001 issue of Nature. The papers from Nature included initial sequence analyses generated by the publicly sponsored Human Genome Project, while Science publications focused on the draft sequence reported by the private company, Celera Genomics.
Because of the importance of these landmark papers, both Science and Nature have provided free and unrestricted access to all articles. An index and links follow.
Introduction. Barbara R. Jasny and Leslie Roberts. Science Apr 11 2003: 277 Full Text
The Human Genome Project: Lessons from Large-Scale Biology. Francis S. Collins, Michael Morgan, Aristides Patrinos. Science Apr 11 2003: 286 Full Text
Realizing the Potential of the Genome Revolution: The Genomes to Life Program. Marvin E. Frazier, Gary M. Johnson, David G. Thomassen, Carl E. Oliver, Aristides Patrinos. Science Apr 11 2003: 290 Full Text
A Vision for the Future of Genomics Research. Francis S. Collins, Eric D. Green, Alan E. Guttmacher, Mark S. Guyer. A blueprint for the genomic era. Nature Apr 24 2003: 835. Full text
Genetics and the Making of Homo sapiens. Sean B. Carroll. Nature Apr 24 2003: 849 Full text
Genome Sequencing: Revelations from a Bread Mould. Jonathan Arnold, Nelson Hilton. Nature Apr 24 2003: 821. Full text
A physical map of the human genome. The International Human Genome Mapping Consortium. Nature 409, 934-941 (15 February 2001) Full Text
The sequence of the human genome. The Celera Genomics Sequencing Team. Science Feb 16 2001: 1304-1351. Full Text
The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X. D. R. Bentley, et al. Nature 409, 942-943 (15 February 2001) Full Text
A physical map of the human Y chromosome. Charles A. Tilford, et al. Nature 409, 943-945 (15 February 2001) Full Text
A high-resolution map of human chromosome 12. Kate T. Montgomery, et al. Nature 409, 945-946 (15 February 2001) Full Text
A physical map of human chromosome 14. Thomas Brüls, et al. Nature 409, 947-948 (15 February 2001) Full Text
Integration of telomere sequences with the draft human genome sequence. H. C. Riethman, et al. Nature 409, 948-951 (15 February 2001) Full Text
Comparison of human genetic and sequence-based physical maps. Adong Yu, et al. Nature 409, 951-953 (15 February 2001) Full Text
Integration of cytogenetic landmarks into the draft sequence of the human genome. V. G. Cheung, et al. Nature 409, 953-958 (15 February 2001) Full Text
Mining the draft human genome. Ewan Birney, et al. Nature 409, 827-828 (15 February 2001) Full Text
Keeping time with the human genome. Jonathan D. Clayton, et al. Nature 409, 829-831 (15 February 2001) Full Text
Expressing the human genome. Rossella Tupler, et al. Nature 409, 832-833 (15 February 2001) Full Text
Functional annotation of mouse genome sequences. Joseph H. Nadeau, et al. Science Feb 16 2001: 1251-1255. Full Text
A genomic perspective on membrane compartment organization. Jason B. Bock, et al. Nature 409, 839-841 (15 February 2001) Full Text
Genomics, the cytoskeleton and motility. Thomas D. Pollard. Nature 409, 842-843 (15 February 2001) Full Text
Can sequencing shed light on cell cycling?. Andrew W. Murray, et al. Nature 409, 844-846 (15 February 2001) Full Text
Evolutionary analyses of the human genome. Wen-hsiung Li, et al. Nature 409, 847-849 (15 February 2001) Full Text
Experimental annotation of the human genome using microarray technology. D. D. Shoemaker, et al. Nature 409, 922-927 (15 February 2001) Full Text
Guide to the draft human genome. Tyra G. Wolfsberg, et al. Nature 409, 824-826 (15 February 2001) Full Text
What if there are only 30,000 human genes?. Jean-Michel Claverie. Science Feb 16 2001: 1255-1257. Full Text
Making sense of the sequence. David J. Galas. Science Feb 16 2001: 1257-1260. Full Text
Our genome unveiled. David Baltimore. Nature 409, 814-816 (15 February 2001) Full Text
Genome speak. Peer Bork, et al. Nature 409, 815 (15 February 2001) Full Text
The maps: Clone by clone by clone. Maynard V. Olson. The public project's sequencing strategy involved producing a map of the human genome and then pinning sequence to it. This helps to avoid errors in the sequence, especially in repetitive regions. Nature 409, 816-818 (15 February 2001) Full Text
The draft sequences: Filling in the gaps. Peer Bork, et al. Nature 409, 818-820 (15 February 2001) Full Text
The draft sequences: Comparing species. Gerald M. Rubin. Nature 409, 820-821 (15 February 2001) Full Text
Dissecting human disease in the postgenomic era. Leena Peltonen and Victor A. McKusick. Science Feb 16 2001: 1224-1229. Full Text
..to a future of genetic medicine. Aravinda Chakravarti. Nature 409, 822-823 (15 February 2001) Full Text
A genomic view of immunology. Aude M. Fahrer, et al. Nature 409, 836-838 (15 February 2001) Full Text
Cancer and genomics . P. Andrew Futreal, et al. Nature 409, 850-852 (15 February 2001). Full Text
Human disease genes. Gerardo Jimenez-Sanchez, et al. Nature 409, 853-855 (15 February 2001) Full Text
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. The International SNP Map Working Group. Nature 409, 928-933 (15 February 2001) Full Text
Single nucleotide polymorphisms: From the evolutionary past. Mark Stoneking. Nature 409, 821-822 (15 February 2001) Full Text
Toward behavioral genomics. Peter McGuffin, et al. Science Feb 16 2001: 1232-1249. Full Text
Learning about addiction from the genome. Eric J. Nestler, et al. Nature 409, 834-835 (15 February 2001) Full Text
Bioinformatics--Trying to swim in a sea of data. David S. Roos. Science Feb 16 2001: 1260-1261. Full Text
Computational comparison of two draft sequences of the human genome. John Aach, et al. Nature 409, 856-859 (15 February 2001) Full Text
Are you ready for the revolution?. Declan Butler. Nature 409, 758-760 (15 February 2001) Full Text
The human genome and our view of ourselves. Svante Pääbo. Science Feb 16 2001: 1219-1220. Full Text
Political issues in the genome era. James M. Jeffords and Tom Daschle. Science Feb 16 2001: 1249-1251. Full Text
Proteomics in genomeland. Stanley Fields. Science Feb 16 2001: 1221-1224. Full Text
Watching genes build a body. Gretchen Vogel. Science Feb 16 2001: 1181. Full Text
What's next for the genome centers?. Elizabeth Pennisi. Science Feb 16 2001: 1204-1207. Full Text
Hunting for collaborators of killer toxins. Jocelyn Kaiser. Science Feb 16 2001: 1207. Full Text
The human genome. Elizabeth Pennisi. Science Feb 16 2001: 1177-1180. Full Text
Comparison shopping. Eliot Marshall. Science Feb 16 2001: 1180-1181. Full Text
Genomania meets the bottom line. David Malakoff and Robert F. Service. Science Feb 16 2001: 1193-1203. Full Text
Can data banks tally profits?. Robert F. Service. Science Feb 16 2001: 1203. Full Text
Will a smaller genome complicate the patent chase?. David Malakoff. Science Feb 16 2001: 1194. Full Text
Controversial from the start. Leslie Roberts. Science Feb 16 2001: 1182-1188. Full Text
A history of the human genome project. Leslie Roberts, et al. Science Feb 9 2001: 1195. Full Text
In their own words. Science Feb 9 2001: 1196. Full Text
What a long, strange trip it's been. Nature 409, 756 - 757 (15 February 2001) Full Text
The human genome. Editorial by Barbara R. Jasny and Donald Kennedy. Science Feb 16 2001: 1153 Summary
Human genomes, public and private. Editorial. Nature Feb 15 2001: 409. Full Text
Molecular structure of nucleic acids: A structure for deoxyribose nucleic acid. J.D. Watson & F. H. C. Crick. Nature 171, 737-734 (1953) Full Text
Science genome map. Science Feb 16 2001: 1218. Full Text
Funny genes / The DNA vault / Genome hubs / Genomes for all. Science Feb 16 2001: 1163 Full Text
The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.
Published from 1989 until 2002, this newsletter facilitated HGP communication, helped prevent duplication of research effort, and informed persons interested in genome research.