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HGP Research Area: Chromosome Mapping

The Human Genome Project was completed in 2003. One of the key research areas was Chromosome Mapping. This page details that research.

Mapping is the construction of a series of chromosome descriptions that depict the position and spacing of unique, identifiable biochemical landmarks, including some genes, that occur on the DNA of chromosomes.

In 1990, DOE initiated projects to enrich the developing chromosome maps with markers for genes. In 1993 this effort led to the establishment of the Integrated Molecular Analysis of Gene Expression (IMAGE) Consortium. IMAGE members developed and arrayed cDNA clones (representing the gene coding regions of the genome) to make them available worldwide. In 2007, the effort was transferred to HudsonAlpha. Numerous other institutes and identities have undertaken mapping efforts.

Area HGP Goal Standard Achieved Date Achieved
Genetic Map 2- to 5-cM resolution map (600 – 1,500 markers) 1-cM resolution map (3,000 markers) September 1994
Physical Map 30,000 STSs 52,000 STSs October 1998
Gene Identification Full-length human cDNAs 15,000 full-length human cDNAs March 2003

For a more detailed explanation of mapping, see the U.S. DOE Primer on Molecular Genetics.

Abstracts

Gene Maps

Single Chromosome Workshops

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Human Genome Project 1990–2003

The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.

Human Genome News

Published from 1989 until 2002, this newsletter facilitated HGP communication, helped prevent duplication of research effort, and informed persons interested in genome research.