Human Genome Project Information. Click to return to home page.

Sponsored by the U.S. Department of Energy Human Genome Program

Human Genome News Archive Edition

Human Genome News, Nov. 1994; 6(4):2

Albert Einstein College of Medicine (AECM)

ALBERT EINSTEIN COLLEGE OF MEDICINE (AECM)
(NIH, established 1993)
RAJU KUCHERLAPATI, Director
CONTACT: Kucherlapati (718/430-2069, Fax: -8776, kucherla@aecom.yu.edu); AECM; 1300 Morris Park Ave.; Bronx, NY 10461.
OTHER KEY RESEARCHERS
Kenneth Kidd (Yale Univ.)
Kenneth Krauter
Perry Miller (Yale Univ.)
David Ward (Yale Univ.)

MAJOR GOALS

  • Construction of a high-resolution map of chromosome 12, integrating the cytogenetic, linkage, and physical maps; localization of all known chromosome 12 genes onto specific yeast artificial chromosomes.

MAJOR ACCOMPLISHMENTS

  • Characterization of a human chromosome 12 cosmid library and mapping of more than 200 cosmids to specific regions of chromosome 12 by fluorescence in situ hybridization.
  • Generation of monomorphic and polymorphic markers from cosmids mapped to chromosome 12.
  • Construction of yeast artificial chromosome contigs covering nearly 40% of the chromosome. Each contig includes polymorphic markers generated by several groups, including Genethon, Univ. of Iowa, CHLC, MMRF, and AECM. Additional markers have been generated from the ends of yeast artificial chromosomes by AECM. The yeast artificial chromosome map also incorporates known chromosome 12 genes.
  • Integration of cytogenetic maps with emerging physical maps by fluorescence in situ hybridization mapping of over 100 individual yeast artificial chromosomes from contigs to metaphase chromosomes.
  • Development of a Sybase-based relational database for chromosome 12 reagents and maps.

AVAILABLE RESOURCES

  • Arrayed chromosome 12 cosmid library for replica plating.
  • Centre d'Etude du Polymorphisme Humain chromosome 12-specific yeast artificial chromosome sublibrary.
  • Sequence tagged site collections for mapped positions of chromosome 12 cosmids, yeast artificial chromosomes, and genes as determined by fluorescence in situ hybridization mapping.

HGMIS staff

Return to Table of Contents

The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v6n4).

Human Genome Project 1990–2003

The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.

Human Genome News

Published from 1989 until 2002, this newsletter facilitated HGP communication, helped prevent duplication of research effort, and informed persons interested in genome research.