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Human Genome News Archive Edition

Human Genome News, Nov. 1994; 6(4):2

Baylor College of Medicine (BCM)

BAYLOR COLLEGE OF MEDICINE (BCM)
(NIH, established 1990)
C. THOMAS CASKEY, Director
David L. Nelson, Associate Director
CONTACTS: Sandra McMurtry, Administrator (713/798-6524, Fax: -5386, mcmurtry@bcm.tmc.edu) or David Nelson (-3122; nelson@bcm.tmc.edu); BCM; One Baylor Plaza; Houston, TX 77030-3498.
OTHER KEY RESEARCHERS
Antonio Baldini
A. Craig Chinault
Robert W. Cottingham, Jr.
Richard A. Gibbs
Gail E. Herman
Charles B. Lawrence
Cheng Chi Lee
James R. Lupski
John M. Shumaker
Randall F. Smith
Huda Y. Zoghbi

MAJOR GOALS

  • Six core facilities provide support for independently funded physical mapping and positional cloning projects and development of technology, with emphasis on human chromosomes 6, 15, 17, and X and the mouse X chromosome.

MAJOR ACCOMPLISHMENTS

  • Identification of several new disease loci, including Fragile X syndrome, myotonic dystrophy (DM), Charcot-Marie-Tooth disease, Kallman syndrome, glycerol kinase deficiency, Miller-Dieker lissencephaly, Lowe syndrome, and spinocerebellar ataxia type1.
  • Identification of >2000 yeast artificial chromosome clones by polymerase chain reaction screening for target chromosomes.
  • Assembly of contigs in target regions (many contigs >1 Mb from X, 17, 6, and 15).
  • Development of methods for yeast artificial chromosome characterization and contig assembly.
  • Development of Genome Data Base-Lite and a library screening and clone characterization database capable of periodic automatic submission to Genome Data Base.
  • Completion of moderate-scale sequencing projects encompassing over 200 kb of human DNA from the X and other chromosomes (including the genes for Duchenne muscular dystrophy, candidate gene for X-inactivation center, Fragile X locus, and DM).
  • Establishment of several hundred cell lines from patients with chromosome-linked disorders.
  • Assembly of a 35-Mb contig in yeast artificial chromosomes for Xp21-ter.
  • Development of a Mosaic browser for integrated yeast artificial chromosome data scanning.

AVAILABLE RESOURCES

  • Total human yeast artificial chromosome libraries (Centre d'Etude du Polymorphisme Humain and Wash. Univ.].
  • Chromosome X yeast artificial chromosome libraries (BCM and CHOP).
  • Chromosome 17 and X cosmid libraries (LANL and LLNL).
  • Screening service for chromosome 17p.
  • Total mouse yeast artificial chromosome libraries (St. Mary's and Imperial Cancer Research Fund). DNA pools available for multistep polymerase chain reaction screening (yaclab@bcm.tcm.edu).
  • Numerous patient cell lines and chromosome mapping cell panels for 6, 17, and X (hybrids, deletions, etc.).
  • Sequence tagged sites and yeast artificial chromosomes for many loci on target chromosomes.
  • Database software.
  • NCHGR predoctoral training grant (Chinault).
  • Quarterly newsletter.

HGMIS staff

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Human Genome Program, U.S. Department of Energy, Human Genome News (v6n4).

Human Genome Project 1990–2003

The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.

Human Genome News

Published from 1989 until 2002, this newsletter facilitated HGP communication, helped prevent duplication of research effort, and informed persons interested in genome research.