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Sponsored by the U.S. Department of Energy Human Genome Program

Human Genome News Archive Edition
Human Genome News, September 1992; 4(3)

U.S. Human Genome Project 5-Year Goals*

(Implemented October 1, 1990)


GENETIC MAPPING


  • Complete a fully connected human genetic map with markers spaced an average of 2 to 5 cM apart and identified by a sequence tagged site (STS).

PHYSICAL MAPPING


  • Assemble STS maps of all human chromosomes, with markers spaced at intervals of approximately 100,000 bp.
  • Generate overlapping sets of cloned DNA or closely spaced unambiguously ordered markers with continuity over lengths of 2 Mb for large parts of the human genome.

SEQUENCING


  • Improve current and develop new methods for large-scale DNA sequencing at a target cost of $0.50 per base pair.
  • Determine the sequence of an aggregate of 10 Mb of human DNA in large continuous stretches in the course of technology development and validation.

MODEL ORGANISMS


  • Prepare a mouse genome genetic map based on DNA markers. Start physical mapping on one or two chromosomes.
  • Sequence an aggregate of about 20 Mb of DNA from a variety of model organisms, focusing on stretches that are 1 Mb long, in the course of developing and validating new and improved DNA sequencing technology.

INFORMATICS


  • Develop effective software and database designs to support large-scale mapping and sequencing projects.
  • Create database tools that provide easy access to up-to-date mapping and sequencing information and allow ready comparison of the data in these data sets.
  • Develop algorithms and analytical tools that can be used in the interpretation of genomic information.

ETHICAL, LEGAL, AND SOCIAL ISSUES


  • Develop programs directed toward understanding the ethical, legal, and social implications of Human Genome Project data. Identify and define the major issues and develop initial policy options to address them.

TRAINING


  • Support research training of pre- and postdoctoral fellows starting in FY 1990. Increase the number of trainees supported until a steady state of about 600 per year is reached by the fifth year.
  • Examine the need for other types of research training in FY 1991.

TECHNOLOGY DEVELOPMENT, TRANSFER


  • Support automated instrumentation and innovative and high-risk technological developments as well as improvements in current technology to meet the needs of the genome project as a whole.
  • Encourage and facilitate the transfer of technologies and of medically important information to the medical community. Enhance the already close working relationships with industry.

*From Understanding Our Genetic Inheritance; The U.S. Human Genome Project: The First Five Years, FY 1991-1995, DOE/ER-0452P, U.S. Department of Health and Human Services and U.S. Department of Energy, April 1990.
HGMIS Staff

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The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v4n3).

Human Genome Project 1990–2003

The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.

Human Genome News

Published from 1989 until 2002, this newsletter facilitated HGP communication, helped prevent duplication of research effort, and informed persons interested in genome research.