Sponsored by the U.S. Department of Energy Human Genome Program
Human Genome News, September 1992; 4(3)
U.S. Human Genome Project 5-Year Goals*
(Implemented October 1, 1990)
- Complete a fully connected human genetic map with markers spaced an average of 2 to 5 cM apart and identified by a sequence tagged site (STS).
- Assemble STS maps of all human chromosomes, with markers spaced at intervals of approximately 100,000 bp.
- Generate overlapping sets of cloned DNA or closely spaced unambiguously ordered markers with continuity over lengths of 2 Mb for large parts of the human genome.
- Improve current and develop new methods for large-scale DNA sequencing at a target cost of $0.50 per base pair.
- Determine the sequence of an aggregate of 10 Mb of human DNA in large continuous stretches in the course of technology development and validation.
- Prepare a mouse genome genetic map based on DNA markers. Start physical mapping on one or two chromosomes.
- Sequence an aggregate of about 20 Mb of DNA from a variety of model organisms, focusing on stretches that are 1 Mb long, in the course of developing and validating new and improved DNA sequencing technology.
- Develop effective software and database designs to support large-scale mapping and sequencing projects.
- Create database tools that provide easy access to up-to-date mapping and sequencing information and allow ready comparison of the data in these data sets.
- Develop algorithms and analytical tools that can be used in the interpretation of genomic information.
ETHICAL, LEGAL, AND SOCIAL ISSUES
- Develop programs directed toward understanding the ethical, legal, and social implications of Human Genome Project data. Identify and define the major issues and develop initial policy options to address them.
- Support research training of pre- and postdoctoral fellows starting in FY 1990. Increase the number of trainees supported until a steady state of about 600 per year is reached by the fifth year.
- Examine the need for other types of research training in FY 1991.
TECHNOLOGY DEVELOPMENT, TRANSFER
- Support automated instrumentation and innovative and high-risk technological developments as well as improvements in current technology to meet the needs of the genome project as a whole.
- Encourage and facilitate the transfer of technologies and of medically important information to the medical community. Enhance the already close working relationships with industry.
*From Understanding Our Genetic Inheritance; The U.S. Human Genome Project: The First Five Years, FY 1991-1995
, DOE/ER-0452P, U.S. Department of Health and Human Services and U.S. Department of Energy, April 1990.
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The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v4n3).