Sponsored by the U.S. Department of Energy Human Genome Program
Human Genome News Archive Edition
In this issue...
HGP and the Private Sector
In the News
Ethical, Legal, and Social Issues
Web, Publications, Resources
Meeting Calendars & Acronyms
Public, Private Sectors Join in Mouse Consortium
Sequencing Results will Spur Discovery of Human Genes and Their Functions
In October, a collaboration was announced to speed up sequencing of the mouse genome and produce a draft map by spring 2001. The Mouse Sequencing Consortium (MSC) consists of six NIH institutes, the Wellcome Trust philanthropy, and three private companies. It provides another example of public and private sectors joining forces to support large-scale genomics research and generate freely available data crucial for basic biomedical research (see related article).
MSC members and their contributions are SmithKline Beecham ($6.5 million), the Merck Genome Research Institute ($6.5 million), Affymetrix, Inc. ($3.5 million), Wellcome Trust ($7.75 million), and NIH ($34 million). Total funding of $58 million will support sequencing for 6 months at three centers: Whitehead Institute (Cambridge), Washington University (St. Louis), and the Sanger Centre in the United Kingdom.
Why the Mouse?
On average, protein-coding regions in the mouse and human genomes are 85% identical. These regions are evolutionarily conserved because they are required for biological functions shared by both organisms. In contrast, noncoding genomic regions are less than 50% identical. When comparing the same DNA regions from human and mouse, therefore, functional elements stand out clearly because of greater similarity.
Data from this project will be invaluable to us in annotating the final draft of the human genome, observed researcher John McPherson (Washington University). It is exciting that we are moving rapidly toward completion of both projects, he said.
Rapid Data Release
The MSC data-release policy calls for raw data (individual DNA sequence traces, about 500 bases long) taken directly from automated instruments to be deposited in two public databases. These are operated by the National Center for Biotechnology Information and the European Bioinformatics Institute. Individual sequences will be assembled into larger units as soon as a working draft is obtained.
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The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.
Published from 1989 until 2002, this newsletter facilitated HGP communication, helped prevent duplication of research effort, and informed persons interested in genome research.