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In this issue...
DOE '99 Oakland Highlights
In the News
Ethical, Legal, and Social Issues
Web, Other Resources, Publications
Meeting Calendars & Acronyms
Preliminary analysis of chromosome 19 sequence data, as reported by Jane Lamerdin (Lawrence Livermore National Laboratory, LLNL) at the Oakland meeting, reaffirms the chromosome's selection as a rich target for gene discovery through genomic sequencing. Lamerdin's group at JGI-LLNL has finished about 10 Mb of genomic sequence and has placed many large (1-Mb) contigs from well-mapped regions in its sequencing queue, including representative contigs from almost every cytogenetic band on the chromosome.
Several sequenced GC-rich areas exhibit a high gene density relative to the rest of the genome—on average 1 gene per 20 to 25 kb. To better understand evolution and subsequent functional diversification, the group currently is sequencing and making a detailed comparison of several clustered chromosome 19 gene families and their orthologs in the mouse. The genes coding for cytochrome P-450 proteins are one such family under study. These proteins are considered part of the detoxification pathway used by eukaryotes (animals, plants, algae, and fungi) to rid themselves of toxins. Other gene families being analyzed include the pregnancy-specific glycoprotein family, multiple zinc finger families, and olfactory receptors.
The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v10n3-4).
The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.